Resveratrol as an anti-cancer agent: A review

被引:480
|
作者
Rauf, Abdur [1 ]
Imran, Muhammad [2 ]
Butt, Masood Sadiq [3 ]
Nadeem, Muhammad [4 ]
Peters, Dennis G. [5 ]
Mubarak, Mohammad S. [6 ]
机构
[1] Univ Swabi, Dept Chem, Khyber Pakhtunkhwa, Pakistan
[2] Imperial Coll Business Studies, Dept Diet & Nutr Sci, Lahore, Pakistan
[3] Agr Univ Faisalabad, Fac Food Nutr & Home Sci, Faisalabad, Pakistan
[4] COMSATS Inst Informat Technol, Dept Environm Sci, Vehari 61100, Pakistan
[5] Indiana Univ, Dept Chem, Bloomington, IN USA
[6] Univ Jordan, Dept Chem, Amman 11942, Jordan
关键词
Resveratrol; chemopreventive agent; human cancers; APOPTOTIC CELL-DEATH; BLADDER-CANCER CELLS; TO-MESENCHYMAL TRANSITION; BREAST EPITHELIAL-CELLS; COLORECTAL-CANCER; DOWN-REGULATION; CYCLE ARREST; IN-VITRO; ESOPHAGEAL ADENOCARCINOMA; MITOCHONDRIAL DYSFUNCTION;
D O I
10.1080/10408398.2016.1263597
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
Owing to their antimicrobial, antioxidant, and anti-inflammatory activity, grapes (Vitis vinifera L.) are the archetypal paradigms of fruits used not only for nutritional purposes, but also for exclusive therapeutics. Grapes are a prominent and promising source of phytochemicals, especially resveratrol, a phytoalexin antioxidant found in red grapes which has both chemopreventive and therapeutic effects against various ailments. Resveratrol's role in reducing different human cancers, including breast, cervical, uterine, blood, kidney, liver, eye, bladder, thyroid, esophageal, prostate, brain, lung, skin, gastric, colon, head and neck, bone, ovarian, and cervical, has been reviewed. This review covers the literature that deals with the anti-cancer mechanism of resveratrol with special reference to antioxidant potential. Furthermore, this article summarizes the literature pertaining to resveratrol as an anti-cancer agent.
引用
收藏
页码:1428 / 1447
页数:20
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