Indenone derivatives:: A novel template for peroxisome proliferator-activated receptor γ (PPARγ) agonists

被引：124
|
作者：
Ahn, Jin Hee
Shin, Mi Sik
Jung, Sun Ho
Kang, Seung Kyu
Kim, Kwang Rok
Rhee, Sang Dal
Jung, Won Hoon
Yang, Sung Don
Kim, Seung Jun
Woo, Joo Rang
Lee, Jeong Hyung
Cheon, Hyae Gyeong [1 ]
Kim, Sung Soo
机构：
[1] Korea Res Inst Chem Technol, Bioorgan Sci Div, Taejon 305600, South Korea
[2] Korea Res Inst Biosci & Biotechnol, Taejon 305333, South Korea
来源：
JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 49卷 / 15期
关键词：
D O I：
10.1021/jm060389m
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Agonists of peroxisome proliferator-activated receptor gamma (PPAR gamma) are of interest as a treatment for diabetes, which prompted the identification of a new class of non-TZD PPAR gamma agonist. Moreover, compound 14c has displayed the most active agonistic activity with an EC50 value of 50 nM, in addition to exhibiting a new binding mode in the X-ray cocrystal structure.
引用
收藏
页码：4781 / 4784
页数：4
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