Activation of ERK and SMAD2 kinases signal the TGF-beta induced and laminin-1 facilitated expression of MMP-3 in synovial fibroblasts.

被引：0
|
作者：
Hoberg, Maik
Rudert, Maximilian
Pap, Thomas
Klein, Gerd
Gay, Steffen
Aicher, Wilhelm K.
机构：
[1] Univ Hosp, WHO Rheumatol Res Ctr, Zurich, Switzerland
[2] Univ Hosp Munster, Div Mol Med Musculoskel Tissue, Munster, Germany
[3] Univ Tubingen, Tubingen, Germany
来源：
ARTHRITIS AND RHEUMATISM | 2006年 / 54卷 / 09期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：S596 / S597
页数：2
相关论文
共 50 条
  • [41] OPG may protect bleomycin-induced pulmonary fibrosis by inhibiting SMAD2/3 dependent TGF-β1 activation
    Weng, D.
    Li, H.
    Ge, B.
    EUROPEAN JOURNAL OF IMMUNOLOGY, 2016, 46 : 1097 - 1097
  • [42] Opg May Protect Bleomycin-Induced Pulmonary Fibrosis By Inhibiting Smad2/3 Dependent Tgf-β1 Activation
    Weng, D.
    Zheng, R.
    Li, H.
    Ge, B.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2017, 195
  • [43] TGF-β Upregulated Mitochondria Mass through the SMAD2/3→C/EBPβ→PRMT1 Signal Pathway in Primary Human Lung Fibroblasts
    Sun, Qingzhu
    Fang, Lei
    Tang, Xuemei
    Lu, Shemin
    Tamm, Michael
    Stolz, Daiana
    Roth, Michael
    JOURNAL OF IMMUNOLOGY, 2019, 202 (01): : 37 - 47
  • [44] Activation of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) is needed for the TGFβ-induced chondrogenic and osteogenic differentiation of mesenchymal stem cells
    Arita, Nestor A.
    Pelaez, Daniel
    Cheung, Herman S.
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 405 (04) : 564 - 569
  • [45] Curcumin inhibits TGF-β1-induced connective tissue growth factor expression through the interruption of Smad2 signaling in human gingival fibroblasts
    Chen, Jung-Tsu
    Wang, Chen-Ying
    Chen, Min-Huey
    JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION, 2018, 117 (12) : 1115 - 1123
  • [46] Interleukin-17 induces human alveolar epithelial to mesenchymal cell transition via the TGF-β1 mediated Smad2/3 and ERK1/2 activation
    Wang, Ting
    Liu, Yuan
    Zou, Jing-Feng
    Cheng, Zhen-Shun
    PLOS ONE, 2017, 12 (09):
  • [47] 2-CARBA-CYCLIC PHOSPHATIDIC ACID SUPPRESSES EXPRESSION OF CARTILAGE DEGRADING ENZYMES SUCH AS MMP-3, MMP-13 AND ADAMTS-4 IN INFLAMMATORY SYNOVIAL FIBROBLASTS AND ARTICULAR CHONDROCYTES INDUCED BY IL-1 BETA AND/OR TNF ALFA
    Masuda, I.
    Okada, K.
    Yamanaka, H.
    Momohara, S.
    OSTEOARTHRITIS AND CARTILAGE, 2017, 25 : S328 - S328
  • [48] Cyclic Phosphatidic Acid (CPA) Suppresses Expression of Cartilage Degrading Enzymes Such As MMP-3, MMP-13 and Adamts-4 in Inflammatory Synovial Fibroblasts and Articular Chondrocytes Induced By IL-1 Beta and/or TNF ALFA
    Masuda, Ikuko
    Okada, Kodo
    Yamanaka, Hisashi
    Momohara, Shigeki
    ARTHRITIS & RHEUMATOLOGY, 2015, 67
  • [49] Evodiae fructus Extract Inhibits Interleukin-1β-Induced MMP-1, MMP-3, and Inflammatory Cytokine Expression by Suppressing the Activation of MAPK and STAT-3 in Human Gingival Fibroblasts In Vitro
    Song, Hyun-Kyung
    Noh, Eun-Mi
    Kim, Jeong-Mi
    You, Yong-Ouk
    Kwon, Kang-Beom
    Lee, Young-Rae
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2021, 2021
  • [50] FOXF1 reverses lung fibroblasts transdifferentiation via inhibiting TGF-β/ SMAD2/3 pathway in silica-induced pulmonary fibrosis
    Hu, Botao
    Zhang, Xuesong
    Fan, Hui
    Jin, Xiaofei
    Qi, Yuanmeng
    Liu, Ruimin
    Li, Xiaoying
    Duan, Meixiu
    Zhang, Chengpeng
    Li, Shiyu
    Yao, Wu
    Hao, Changfu
    INTERNATIONAL IMMUNOPHARMACOLOGY, 2024, 133
12345