Alkoxy substituted bicyclic pyrimidine modulators of gamma secretase

被引:0
|
作者
Zhang, Yunhui [1 ]
Xie, Kai [1 ]
Mercer, Stephen [1 ]
Lin, Alan [1 ]
Toyn, Jeremy [1 ]
Ahlijanian, Michael [1 ]
Lentz, Kimberley [1 ]
Macor, John [2 ]
Thompson, Lorin [1 ]
Olson, Richard [1 ]
Boy, Kenneth [1 ]
机构
[1] Bristol Myers Squibb, Wallingford, CT USA
[2] Bristol Myers Squibb, Princeton, NJ USA
关键词
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
434
引用
收藏
页数:1
相关论文
共 50 条
  • [21] Quinazolinones as γ-secretase modulators
    Fischer, Christian
    Shah, Sanjiv
    Hughes, Bethany L.
    Nikov, George N.
    Crispino, Jamie L.
    Middleton, Richard E.
    Szewczak, Alexander A.
    Munoz, Benito
    Shearman, Mark S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (02) : 773 - 776
  • [22] Inhibitors and modulators of β- and γ-secretase
    Schmidt, Boris
    Baumann, Stefanie
    Braun, Hannes A.
    Larbig, Gregor
    CURRENT TOPICS IN MEDICINAL CHEMISTRY, 2006, 6 (04) : 377 - 392
  • [23] Steroids as γ-secretase modulators
    Jung, Joo In
    Ladd, Thomas B.
    Kukar, Thomas
    Price, Ashleigh R.
    Moore, Brenda D.
    Koo, Edward H.
    Golde, Todd E.
    Felsenstein, Kevin M.
    FASEB JOURNAL, 2013, 27 (09): : 3775 - 3785
  • [24] Aminothiazoles as γ-secretase modulators
    Luebbers, Thomas
    Flohr, Alexander
    Jolidon, Synese
    David-Pierson, Pascale
    Jacobsen, Helmut
    Ozmen, Laurence
    Baumann, Karlheinz
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (21) : 6554 - 6558
  • [25] Iminoheterocycles as γ-secretase modulators
    Caldwell, John P.
    Bennett, Chad E.
    McCracken, Troy M.
    Mazzola, Robert D.
    Bara, Thomas
    Buevich, Alexei
    Burnett, Duane A.
    Chu, Inhou
    Cohen-Williams, Mary
    Josein, Hubert
    Hyde, Lynn
    Lee, Julie
    McKittrick, Brian
    Song, Lixin
    Terracina, Giuseppe
    Voigt, Johannes
    Zhang, Lili
    Zhu, Zhaoning
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (18) : 5380 - 5384
  • [26] γ-Secretase inhibitors and modulators
    Golde, Todd E.
    Koo, Edward H.
    Felsenstein, Kevin M.
    Osborne, Barbara A.
    Miele, Lucio
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2013, 1828 (12): : 2898 - 2907
  • [27] Triazoles as γ-secretase modulators
    Fischer, Christian
    Zultanski, Susan L.
    Zhou, Hua
    Methot, Joey L.
    Brown, W. Colby
    Mampreian, Dawn M.
    Schell, Adam J.
    Shah, Sanjiv
    Nuthall, Hugh
    Hughes, Bethany L.
    Smotrov, Nadja
    Kenific, Candia M.
    Cruz, Jonathan C.
    Walker, Deborah
    Bouthillette, Melanie
    Nikov, George N.
    Savage, Dan F.
    Jeliazkova-Mecheva, Valentina V.
    Diaz, Damaris
    Szewczak, Alexander A.
    Bays, Nathan
    Middleton, Richard E.
    Munoz, Benito
    Shearman, Mark S.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2011, 21 (13) : 4083 - 4087
  • [28] Discovery of tetrahydroindazoles as a novel class of potent and in vivo efficacious gamma secretase modulators
    Gerlach, Kai
    Hobson, Scott
    Eickmeier, Christian
    Gross, Ulrike
    Braun, Clemens
    Sieger, Peter
    Garneau, Michel
    Hoerer, Stefan
    Heine, Niklas
    BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 26 (12) : 3227 - 3241
  • [29] Gamma-secretase modulators: a promising route for the treatment of Alzheimer's disease
    Nordvall, Gunnar
    Lundkvist, Johan
    Sandin, Johan
    FRONTIERS IN MOLECULAR NEUROSCIENCE, 2023, 16
  • [30] Design and synthesis of novel methoxypyridine-derived gamma-secretase modulators
    Rynearson, Kevin D.
    Buckle, Ronald N.
    Herr, R. Jason
    Mayhew, Nicholas J.
    Chen, Xinchao
    Paquette, William D.
    Sakwa, Samuel A.
    Yang, Jinhai
    Barnes, Keith D.
    Nguyen, Phuong
    Mobley, William C.
    Johnson, Graham
    Lin, Juinn H.
    Tanzi, Rudolph E.
    Wagner, Steven L.
    BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 28 (22)