Adolescent Idiopathic Scoliosis and the Single-nucleotide Polymorphism of the Growth Hormone Receptor and IGF-1 Genes

被引:24
|
作者
Yang, Yong [1 ]
Wu, Zhihong [1 ]
Zhao, Taimao [1 ]
Wang, Hai [1 ]
Zhao, Dong [2 ]
Zhang, Jianguo [1 ]
Wang, Yipeng [1 ]
Ding, Yaozhong [3 ]
Qiu, Guixing [1 ]
机构
[1] Chinese Acad Med Sci, Dept Orthoped, Peking Union Med Coll, Beijing 100037, Peoples R China
[2] Tianjin Hosp, Dept Orthoped, Tianjin, Peoples R China
[3] Mt Sinai Sch Med, Recanati Miller Transplantat Inst, New York, NY USA
基金
中国国家自然科学基金;
关键词
D O I
10.3928/01477447-20090511-08
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
The etiology of adolescent idiopathic scoliosis is undetermined despite years of research. A number of hypotheses have been postulated to explain its development, including growth abnormalities. The irregular expression of growth hormone and insulin-like growth factor-1 (IGF-1) may disturb hormone metabolism, result in a gross asymmetry, and promote the progress of adolescent idiopathic scoliosis. Initial association studies in complex diseases have demonstrated the power of candidate gene association. Prior to our study, 1 study in this field had a negative result. A replicable study is vital for reliability. To determine the relationship of growth hormone receptor and IGF-1 genes with adolescent idiopathic scoliosis, a population-based association study was performed. Single nucleotide polymorphisms with potential function were selected from candidate genes and a distribution analysis was performed. A conclusion was made confirming the insufficiency of an association between adolescent idiopathic scoliosis and the single-nucleotide polymorphism of the growth hormone receptor and IGF-1 genes in Han Chinese. Copyright ® 2009 SLACK Incorporated. All rights reserved.
引用
收藏
页码:411 / 411
页数:1
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