Characterization of folic acid-PAMAM conjugates: drug loading efficacy and dendrimer morphology

被引：19
|
作者：
Chanphai, P. [1 ]
Tajmir-Riahi, H. A. [1 ]
机构：
[1] Univ Quebec Trois Rivieres, Dept Chem Biochem & Phys, CP 500, Trois Rivieres, PQ G9A 5H7, Canada
来源：
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS | 2018年 / 36卷 / 07期
基金：
加拿大自然科学与工程研究理事会;
关键词：
folic acid; dendrimer; conjugation; loading efficacy; thermodynamic; TEM; modeling; HUMAN SERUM-ALBUMIN; TARGETED DELIVERY; POLY(AMIDOAMINE) DENDRIMERS; THERMODYNAMIC ANALYSIS; STARBURST DENDRIMERS; NANOPARTICLES; THERAPEUTICS; DOXORUBICIN; NANOTECHNOLOGY; COMPLEXES;
D O I：
10.1080/07391102.2017.1341339
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We report the loading efficacy of folic acid (FA) by polyamidoamine (PAMAM-G3 and PAMAM-G4) nanoparticles in aqueous solution at physiological pH. Thermodynamic parameters Delta H = -47.57 (kJMol(-1)), Delta S = -122.78 (JMol(-1), K-1) and Delta G = -10.96 (kJMol(-1)) showed FA-PAMAM bindings occur via H-bonding and van der Waals contacts. The stability of acid-PAMAM conjugate increased as polymer size increased. The acid loading efficacy was 40 to 50%. TEM images exhibited major polymer morphological changes upon acid encapsulation. PAMAM dendrimers are capable of FA delivery in vitro.
引用
收藏
页码：1918 / 1924
页数：7
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