Pneumococcal surface protein C contributes to sepsis caused by Streptococcus pneumoniae in mice

被引：64
|
作者：
Iannelli, F [1 ]
Chiavolini, D [1 ]
Ricci, S [1 ]
Oggioni, MR [1 ]
Pozzi, G [1 ]
机构：
[1] Univ Siena, Lab Mol Microbiol & Biotechnol, Policlin Le Scotte, Dept Mol Biol, I-53100 Siena, Italy
来源：
INFECTION AND IMMUNITY | 2004年 / 72卷 / 05期
关键词：
D O I：
10.1128/IAI.72.5.3077-3080.2004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The role of pneumococcal surface protein C (PspC; also called SpsA, CbpA, and Hic) in sepsis by Streptococcus pneumoniae was investigated in a murine infection model. The pspC gene was deleted in strains D39 (type 2) and A66 (type 3), and the mutants were tested by being injected intravenously into mice. The animals infected with the mutant strains showed a significant increase in survival, with the 50% lethal dose up to 250-fold higher than that for the wild type. Our findings indicate that PspC affords a decisive contribution to sepsis development.
引用
收藏
页码：3077 / 3080
页数：4
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