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Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
被引:74
|作者:
Zeng, Chui-Mian
[1
,2
]
Chen, Zhe
[3
]
Fu, Li
[1
,2
]
机构:
[1] Shenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
[2] Shenzhen Univ, Sch Med, Carson Int Canc Res Ctr, Shenzhen 518060, Peoples R China
[3] Zhejiang Chinese Med Univ, Zhejiang Hosp Tradit Chinese Med, Zhejiang Key Lab Gastrointestinal Pathophysiol, Hangzhou 310006, Zhejiang, Peoples R China
基金:
国家重点研发计划;
中国国家自然科学基金;
关键词:
frizzled receptors;
WNT signaling pathway;
cancer therapy;
antibody;
small molecule inhibitor;
WNT/BETA-CATENIN PATHWAY;
CELL LUNG-CANCER;
EPITHELIAL-MESENCHYMAL TRANSITION;
NEGATIVE BREAST-CANCER;
ACUTE MYELOID-LEUKEMIA;
HUMAN SYNOVIAL SARCOMA;
STEM-LIKE CELLS;
DOWN-REGULATION;
BETA-CATENIN;
SIGNALING PATHWAY;
D O I:
10.3390/ijms19051543
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers.
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