Frizzled Receptors as Potential Therapeutic Targets in Human Cancers
被引:74
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作者:
Zeng, Chui-Mian
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机构:
Shenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
Shenzhen Univ, Sch Med, Carson Int Canc Res Ctr, Shenzhen 518060, Peoples R ChinaShenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
Zeng, Chui-Mian
[1
,2
]
Chen, Zhe
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机构:
Zhejiang Chinese Med Univ, Zhejiang Hosp Tradit Chinese Med, Zhejiang Key Lab Gastrointestinal Pathophysiol, Hangzhou 310006, Zhejiang, Peoples R ChinaShenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
Chen, Zhe
[3
]
Fu, Li
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机构:
Shenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
Shenzhen Univ, Sch Med, Carson Int Canc Res Ctr, Shenzhen 518060, Peoples R ChinaShenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
Fu, Li
[1
,2
]
机构:
[1] Shenzhen Univ, Sch Med, Dept Pharmacol, Guangdong Key Lab Genome Stabil & Dis Prevent, Shenzhen 518060, Peoples R China
[2] Shenzhen Univ, Sch Med, Carson Int Canc Res Ctr, Shenzhen 518060, Peoples R China
[3] Zhejiang Chinese Med Univ, Zhejiang Hosp Tradit Chinese Med, Zhejiang Key Lab Gastrointestinal Pathophysiol, Hangzhou 310006, Zhejiang, Peoples R China
frizzled receptors;
WNT signaling pathway;
cancer therapy;
antibody;
small molecule inhibitor;
WNT/BETA-CATENIN PATHWAY;
CELL LUNG-CANCER;
EPITHELIAL-MESENCHYMAL TRANSITION;
NEGATIVE BREAST-CANCER;
ACUTE MYELOID-LEUKEMIA;
HUMAN SYNOVIAL SARCOMA;
STEM-LIKE CELLS;
DOWN-REGULATION;
BETA-CATENIN;
SIGNALING PATHWAY;
D O I:
10.3390/ijms19051543
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cell proliferation, formation of neural synapses, and many other processes in developing and adult organisms. In this review, we will introduce the basic structural features and review the biological function and mechanism of FZDs in the progression of human cancers, followed by an analysis of clinical relevance and therapeutic potential of FZDs. We will focus on the development of antibody-based and small molecule inhibitor-based therapeutic strategies by targeting FZDs for human cancers.
机构:
Peking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Liu, Hui-yu
Sun, Xiao-jiao
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机构:
Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Sun, Xiao-jiao
Xiu, Si-yu
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Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Xiu, Si-yu
Zhang, Xiang-yu
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Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Zhang, Xiang-yu
Wang, Zhi-qi
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Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Wang, Zhi-qi
Gu, Yan-lun
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机构:
Peking Univ First Hosp, Dept Pharm, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Gu, Yan-lun
Yi, Chu-xiao
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机构:
Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Yi, Chu-xiao
Liu, Jun-yan
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机构:
Peking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Liu, Jun-yan
Dai, Yu-song
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机构:
Peking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Dai, Yu-song
Yuan, Xia
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Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Yuan, Xia
Liao, Hua-peng
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机构:
Yizhang Cty Peoples Hosp, Chenzhou 424200, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Liao, Hua-peng
Liu, Zhen-ming
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机构:
Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Liu, Zhen-ming
Pang, Xiao-cong
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机构:
Peking Univ First Hosp, Dept Pharm, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Pang, Xiao-cong
Li, Tian-cheng
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机构:
Peking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
Capital Med Univ, Beijing Chaoyang Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R ChinaPeking Univ First Hosp, Dept Otorhinolaryngol Head & Neck Surg, Beijing 100034, Peoples R China
机构:
Jilin Normal Univ, Sch Life Sci, Siping 136000, Peoples R China
Jilin Univ, Minist Educ, Sch Life Sci, Key Lab Mol Enzymol & Engn, Changchun 130012, Jilin, Peoples R China
Univ Ottawa, Dept Chem & Biol Engn, Ottawa, ON K1N 6N5, CanadaJilin Normal Univ, Sch Life Sci, Siping 136000, Peoples R China
Wang, Hong-Zhen
Yang, Si-Han
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机构:
Jilin Normal Univ, Sch Life Sci, Siping 136000, Peoples R ChinaJilin Normal Univ, Sch Life Sci, Siping 136000, Peoples R China
Yang, Si-Han
Li, Gui-Ying
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机构:
Jilin Univ, Minist Educ, Sch Life Sci, Key Lab Mol Enzymol & Engn, Changchun 130012, Jilin, Peoples R ChinaJilin Normal Univ, Sch Life Sci, Siping 136000, Peoples R China
Li, Gui-Ying
Cao, Xudong
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机构:
Univ Ottawa, Dept Chem & Biol Engn, Ottawa, ON K1N 6N5, CanadaJilin Normal Univ, Sch Life Sci, Siping 136000, Peoples R China
机构:
Juntendo Univ, Grad Sch Med, Dept Biochem, Tokyo, JapanJuntendo Univ, Grad Sch Med, Dept Biochem, Tokyo, Japan
Yokomizo, Takehiko
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机构:
Nakamura, Motonao
Shimizu, Takao
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机构:
Univ Tokyo, Fac Med, Dept Lipid, Tokyo, Japan
Natl Ctr Global Hlth & Med, Dept Lipid Signaling, Tokyo, JapanJuntendo Univ, Grad Sch Med, Dept Biochem, Tokyo, Japan