Reprogrammed induced pluripotent stem cells: how suitable could they be in reproductive medicine?

被引：5

作者：

Ensenat-Waser, Roberto ^{[1
]}

Pellicer, Antonio ^{[2
]}

Simon, Carlos ^{[1
,2
]}

机构：

[1] Prince Felipe Res Ctr CIFP, Spanish Stem Cell Bank, Valencia 46013, Spain

[2] Univ Valencia, FIVI, Valencia, Spain

来源：

FERTILITY AND STERILITY | 2009年 / 91卷 / 04期

关键词：

reprogramming; iPS; gametes; pluripotency; germ-line; fertility; NUCLEAR TRANSFER; SOMATIC-CELLS; IPS CELLS; IN-VITRO; DIFFERENTIATION; GENERATION; INDUCTION;

D O I：

10.1016/j.fertnstert.2008.12.034

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Human embryonic stem cells have the greatest potential for regenerative and reproductive medicine; unfortunately, their full application is limited by ethical and technical problems. In order to overcome these problems and get patient specific pluripotent cells from somatic cells, the field of reprogramming has moved to the generation of induced pluripotent stem cells by overexpression of four transcription factors after viral infection of the patient's somatic cells. In the present paper we review the limitations and milestones of this technique in both regenerative and reproductive medicine. (Fertil Steril (R) 2009;91.:971-4. (C) 2009 by American Society for Reproductive Medicine.)

引用

页码：971 / 974

页数：4

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