Gliomas presenting after age 10 in individuals with neurofibromatosis type 1 (NF1)

被引：106
|
作者：
Gutmann, DH
Rasmussen, SA
Wolkenstein, P
MacCollin, MM
Guha, A
Inskip, PD
North, KN
Poyhonen, M
Birch, PH
Friedman, JM
机构：
[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA
[2] Ctr Dis Control & Prevent, Natl Ctr Birth Defects & Dev Disabil, Atlanta, GA USA
[3] Univ Paris 12, Hop Henri Mondor, AP HP, Dept Dermatol, F-94010 Creteil, France
[4] Neurosci Ctr MGH E, Charlestown, MA USA
[5] Univ Toronto, Dept Neurosurg, Toronto, ON, Canada
[6] NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA
[7] Univ Sydney, Dept Paediat & Child Hlth, Sydney, NSW 2006, Australia
[8] Family Federat Finland, Dept Med Genet, Helsinki, Finland
[9] Univ British Columbia, Dept Med Genet, Vancouver, BC V5Z 1M9, Canada
来源：
NEUROLOGY | 2002年 / 59卷 / 05期
关键词：
D O I：
10.1212/WNL.59.5.759
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Children with neurofibromatosis 1 (NF1) often develop low-grade gliomas, but brain tumors are infrequently encountered in adults with NF1. The authors present evidence from two clinical series, one including patients known to have NF1 and another focusing on adults with new onset brain tumors, that suggests an association between NF1 and symptomatic gliomas in older individuals. They also summarize the clinical data on 17 adolescents or adults with NF1 and symptomatic gliomas. The findings suggest that individuals with NF1 are at increased risk of developing gliomas throughout their lives.
引用
收藏
页码：759 / 761
页数：3
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