Naturally occurring bioactive Cyclobutane-containing (CBC) alkaloids in fungi, fungal endophytes, and plants

被引：142
|
作者：
Dembitsky, Valery M. [1 ]
机构：
[1] Inst Drug Discovery, IL-91451 Jerusalem, Israel
来源：
PHYTOMEDICINE | 2014年 / 21卷 / 12期
关键词：
Fungi; Fungal endophytes; Plant; Alkaloids; Activities; Cyclobutane; PENICILLIUM-CRUSTOSUM; TREMORGENIC MYCOTOXINS; PENITREM-A; STRUCTURE ELUCIDATION; CARBAZOLE ALKALOIDS; TROPANE ALKALOIDS; ERGOT ALKALOIDS; FATTY-ACIDS; METABOLITES; INHIBITORS;
D O I：
10.1016/j.phymed.2014.07.005
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
This article focuses on the occurrence and biological activities of cyclobutane-containing (CBC) alkaloids obtained from fungi, fungal endophytes, and plants. Naturally occurring CBC alkaloids are of particular interest because many of these compounds display important biological activities and possess antitumour, antibacterial, antimicrobial, antifungal, and immunosuppressive properties. Therefore, these compounds are of great interest in the fields of medicine, pharmacology, medicinal chemistry, and the pharmaceutical industry. Fermentation and production of CBC alkaloids by fungi and/or fungal endophytes is also discussed. This review presents the structures and describes the activities of 98 CBC alkaloids. (C) 2014 Published by Elsevier GmbH.
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页码：1559 / 1581
页数：23
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