Nickel-Catalyzed Mizoroki-Heck/Amination Cascade Reactions of o-Dihaloarenes with Allylamines: Synthesis of Indoles

被引：12

作者：

Chen, Xu ^{[1
,2
,3
]}

Lin, Jin ^{[1
,2
,3
]}

Wang, Biao ^{[1
,2
,3
]}

Tian, Xu ^{[1
,2
,3
]}

机构：

[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China

[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China

[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2020年 / 22卷 / 19期

关键词：

CROSS-COUPLING REACTIONS; HECK REACTION; ARYL; AMINATION; CHLORIDES; HETEROCYCLES; COMPLEXES; PRECATALYSTS; ARYLATION; EFFICIENT;

D O I：

10.1021/acs.orglett.0c02909

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient Mizoroki-Heck/amination cascade reaction of o-dihaloarenes with allylamines has been developed using nickel and IPr carbene ligand as catalyst. This protocol enables the synthesis of a broad range of substituted indoles by a cascade process, from readily available starting materials. Mechanistic studies suggest that the Mizoroki-Heck reaction occurred first under IPr-nickel catalysis.

引用

下载

页码：7704 / 7708

页数：5

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