Nickel-Catalyzed Mizoroki-Heck/Amination Cascade Reactions of o-Dihaloarenes with Allylamines: Synthesis of Indoles

被引：12
|
作者：
Chen, Xu [1 ,2 ,3 ]
Lin, Jin [1 ,2 ,3 ]
Wang, Biao [1 ,2 ,3 ]
Tian, Xu [1 ,2 ,3 ]
机构：
[1] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Target & Clin Pharmacol, Guangzhou 511436, Guangdong, Peoples R China
[2] Guangzhou Med Univ, Sch Pharmaceut Sci, State Key Lab Resp Dis, Guangzhou 511436, Guangdong, Peoples R China
[3] Guangzhou Med Univ, Affiliated Hosp 5, Guangzhou 511436, Guangdong, Peoples R China
来源：
ORGANIC LETTERS | 2020年 / 22卷 / 19期
关键词：
CROSS-COUPLING REACTIONS; HECK REACTION; ARYL; AMINATION; CHLORIDES; HETEROCYCLES; COMPLEXES; PRECATALYSTS; ARYLATION; EFFICIENT;
D O I：
10.1021/acs.orglett.0c02909
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient Mizoroki-Heck/amination cascade reaction of o-dihaloarenes with allylamines has been developed using nickel and IPr carbene ligand as catalyst. This protocol enables the synthesis of a broad range of substituted indoles by a cascade process, from readily available starting materials. Mechanistic studies suggest that the Mizoroki-Heck reaction occurred first under IPr-nickel catalysis.
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页码：7704 / 7708
页数：5
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