Clinical and Dermoscopic Evaluation of Melanocytic Lesions in Patients with Chronic Graft Versus Host Disease

被引：1

作者：

Barreiro-Capurro, Alicia ^{[1
,2
]}

Manuel Mascaro, Jose, Jr. ^{[1
]}

Alejo Galindo, Beatriz ^{[1
]}

Giavedoni, Priscila ^{[3
]}

Carrera, Cristina ^{[1
,2
]}

Alos, Llucia ^{[4
]}

Puig, Susana ^{[1
,2
]}

Malvehy, Josep ^{[1
,2
]}

机构：

[1] Barcelona Univ, IDIBAPS, Dept Dermatol, Melanoma Unit,Hosp Clin Barcelona, Barcelona, Spain

[2] Barcelona Univ, Ctr Invest Biomed Red Enfermedades Raras CIBERER, Inst Salud Carlos III, Barcelona, Spain

[3] Barcelona Univ, Dept Dermatol, Barcelona, Spain

[4] Barcelona Univ, Dept Pathol, IDIBAPS, Hosp Clin Barcelona, Barcelona, Spain

来源：

ACTA DERMATO-VENEREOLOGICA | 2019年 / 99卷 / 09期

关键词：

chronic graft versus host disease; naevi; dermoscopy; digital follow-up; melanoma; REFLECTANCE CONFOCAL MICROSCOPY; SKIN-LESIONS; ABCD RULE; FOLLOW-UP; MELANOMA; NEVI; RECIPIENTS; TRANSPLANTATION; DERMATOSCOPY; DIAGNOSIS;

D O I：

10.2340/00015555-3194

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Patients treated with haematopoietic stem cell transplantation are at increased risk of cutaneous malignant neoplasms. There are no reports on the characteristics of melanocytic lesions in patients with chronic graft versus host disease and the value of recognizing these difficult lesions in high-risk patients. The objective of this study is to describe the clinical and dermoscopic characteristics of melanocytic lesions in patients with chronic graft versus host disease in order to understand their morphology. A prospective cross-sectional study was performed; 10 melanocytic lesions on the trunk and extremities were selected from each patient. A statistically significant association was found between regression and high total dermoscopic score and 7-point checklist score. Lesions were excised or included in short-term digital follow-up. Melanocytic lesions in patients with chronic graft versus host disease developing after allogeneic-haematopoietic stem cell transplantation exhibit marked structural and colour changes similar to melanoma. This is believed to result from the inflammatory process associated with graft versus host disease.

引用

页码：777 / 782

页数：6

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