BIOSENSOR BASED ON ALL-POLYMER RESONANT MICROBEAMS

被引：5
|
作者：
Schmid, S. [1 ]
Waegli, P. [1 ]
Hierold, C. [1 ]
机构：
[1] Swiss Fed Inst Technol, Dept Mech & Proc Engn, Zurich, Switzerland
来源：
IEEE 22ND INTERNATIONAL CONFERENCE ON MICRO ELECTRO MECHANICAL SYSTEMS (MEMS 2009) | 2009年
关键词：
SENSORS; DNA;
D O I：
10.1109/MEMSYS.2009.4805378
中图分类号：
TM [电工技术]; TN [电子技术、通信技术];
学科分类号：
0808 ; 0809 ;
摘要：
We present all-polymer resonant microbeams which can detect the adsorption of streptavidin and DNA on the surface in aqueous solution with a high selectivity. The polymer surface allows the direct functionalization with the receptor biomolecules without intermediate Au-layer. The highly sensitive resonant microbeams offer a low-cost system for disposable and label-free biosensing applications. Minimal analyte (streptavidin) concentrations of 0.025 mu g/ml were detected causing an oscillation frequency shift of 1.9%. 0.13 nmol/ml of 17-mer single-stranded DNA could be selectively detected causing a frequency change of 0.9%.
引用
收藏
页码：300 / 303
页数：4
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