Direct N-acylation of azoles via a metal-free catalyzed oxidative cross-coupling strategy

被引：72
|
作者：
Zhao, Jingjing [1 ,2 ]
Li, Pan [1 ]
Xia, Chungu [1 ]
Li, Fuwei [1 ]
机构：
[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China
[2] Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
来源：
CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 36期
基金：
中国国家自然科学基金;
关键词：
C-H BOND; ONE-POT SYNTHESIS; EFFICIENT SYNTHESIS; DIRECT AMIDATION; ALPHA-DIKETONES; ALDEHYDES; AMIDES; RADICALS; ADJACENT; AMINES;
D O I：
10.1039/c4cc01587h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The KI-catalyzed N-acylation of azoles via direct oxidative coupling of C-H and N-H bonds has been developed. It could be smoothly scaled up to gram synthesis of acyl azoles. The reaction occurred by the coupling of acyl radicals and azoles to form the acyl azole radical anion, followed by its further oxidation.
引用
收藏
页码：4751 / 4754
页数：4
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