DNMT3A R882H MUTANTS DOMINANTLY INHIBIT ACTIVE DNMT3A TETRAMERS IN AML

被引：0
|
作者：
不详
机构：
来源：
CANCER DISCOVERY | 2014年 / 4卷 / 05期
关键词：
D O I：
10.1158/2159-8290.CD-RW2014-075
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
引用
收藏
页码：508 / 508
页数：1
相关论文
共 50 条
  • [31] Whole-Genome Bisulfite Sequencing of Primary AML Cells with the DNMT3A R882H Mutation Identifies Regions of Focal Hypomethylation That Are Associated with Open Chromatin
    Spencer, David H.
    Al-Khalil, Bilal
    Russler-Germain, David
    Lamprecht, Tamara
    Havey, Nicole
    Fulton, Robert S.
    O'Laughlin, Michelle
    Fronick, Catrina
    Wilson, Richard K.
    Ley, Timothy J.
    BLOOD, 2014, 124 (21)
  • [32] Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients
    Yuan, Xiao-Qing
    Chen, Peng
    Du, Yin-Xiao
    Zhu, Ke-Wei
    Zhang, Dao-Yu
    Yan, Han
    Liu, Han
    Liu, Yan-Ling
    Cao, Shan
    Zhou, Gan
    Zeng, Hui
    Chen, Shu-Ping
    Zhao, Xie-Lan
    Yang, Jing
    Zeng, Wen-Jing
    Chen, Xiao-Ping
    JOURNAL OF TRANSLATIONAL MEDICINE, 2019, 17 (1)
  • [33] Mechanistic insights on the DNA methylation by DNMT3a mutants observed in AML patients
    Khrabrova, D.
    Tolkacheva, A.
    Loiko, A.
    Kirsanova, O.
    Cherepanova, N.
    Gromova, E.
    FEBS OPEN BIO, 2019, 9 : 157 - 157
  • [34] Gene Correction of DNMT3A:R882H in Primary Human AML Demonstrates That This Mutation Is Not Required for Disease Maintenance, but Is Associated with Increased Leukemia Stem Cell Frequency
    Koehnke, Thomas
    Karigane, Daiki
    Hilgart, Eleanor
    Kayamori, Kensuke
    Fan, Amy C.
    Collins, Cailin T.
    Suchy, Fabian P.
    Rangavajhula, Athreya S.
    Feng, Yang
    Nakauchi, Yusuke
    Martinez-Montes, Eduardo
    Koldobskiy, Michael
    Feinberg, Andy
    Majeti, Ravindra
    BLOOD, 2023, 142
  • [35] Influence of DNMT3A R882 mutations on AML prognosis determined by the allele ratio in Chinese patients
    Xiao-Qing Yuan
    Peng Chen
    Yin-Xiao Du
    Ke-Wei Zhu
    Dao-Yu Zhang
    Han Yan
    Han Liu
    Yan-Ling Liu
    Shan Cao
    Gan Zhou
    Hui Zeng
    Shu-Ping Chen
    Xie-Lan Zhao
    Jing Yang
    Wen-Jing Zeng
    Xiao-Ping Chen
    Journal of Translational Medicine, 17
  • [36] DNMT3A MUTATIONS ARE NOT A RELIABLE MARKER OF MRD IN AML
    Alfonso, V.
    Iaccarino, L.
    Ottone, T.
    Maurillo, L.
    Buccisano, F.
    Mancini, M.
    Cicconi, L.
    Lavorgna, S.
    Venditti, A.
    Consalvo, M. Irno
    Angelini, D. F.
    Battistini, L.
    Del Principe, M. I.
    Voso, M. T.
    Lo-Coco, F.
    HAEMATOLOGICA, 2016, 101 : S47 - S48
  • [37] DNMT3A mutations in AML: A new prognostic factor?
    Schwarz, Jiri
    Markova, Jana
    LEUKEMIA RESEARCH, 2013, 37 (11) : 1432 - 1433
  • [38] DNMT3A Mutations Are not a Reliable Marker of MRD in AML
    Alfonso, V.
    Iaccarino, L.
    Ottone, T.
    Maurillo, L.
    Buccisano, F.
    Mancini, M.
    Cicconi, L.
    Lavorgna, S.
    Venditti, A.
    Consalvo, M. Irno
    Angelini, D. F.
    Battistini, L.
    Del Principe, M. I.
    Voso, M. T.
    Lo-Coco, F.
    ANNALS OF HEMATOLOGY, 2017, 96 : S62 - S63
  • [39] Gene expression profiling of the DNMT3A R882 mutation in acute leukemia
    Huang, Xiangnan
    Ma, Daoxin
    Dong, Wenhao
    Li, Peng
    Lu, Ting
    He, Na
    Tian, Tian
    Liu, Na
    Du, Yahui
    Ji, Chunyan
    ONCOLOGY LETTERS, 2013, 6 (01) : 268 - 274
  • [40] DNMT3A Mutants Are Enriched in NPMc plus AML and Associated with Adverse Outcome in Childhood AML
    Ries, Rhonda E.
    Ma, Xiaotu
    Tregnago, Claudia
    Alonzo, Todd A.
    Wang, Jim
    Hylkema, Tiffany
    Huang, Benjamin J.
    Torabi, Alireza
    Peplinski, Jack H.
    Wallace, Logan K.
    Aplenc, Richard
    Gamis, Alan S.
    Tarlock, Katherine
    Locatelli, Franco
    Pigazzi, Martina
    Meshinchi, Soheil
    BLOOD, 2023, 142
12345