Mouse b-wave mutants

被引：41
|
作者：
Pardue, Machelle T. [1 ,2 ]
Peachey, Neal S. [3 ,4 ,5 ]
机构：
[1] Atlanta VA Med Ctr, Rehabil Res & Dev Ctr Excellence, Decatur, GA 30030 USA
[2] Emory Univ, Sch Med, Dept Ophthalmol, Atlanta, GA 30322 USA
[3] Louis Stokes Cleveland VA Med Ctr, Res Serv 151W, Cleveland, OH 44106 USA
[4] Cleveland Clin, Cole Eye Inst, Cleveland, OH 44195 USA
[5] Case Western Reserve Univ, Cleveland Clin Lerner Coll Med, Dept Ophthalmol, Cleveland, OH 44195 USA
来源：
DOCUMENTA OPHTHALMOLOGICA | 2014年 / 128卷 / 02期
基金：
美国国家卫生研究院;
关键词：
Electroretinogram; Retina; b-Wave; Depolarizing bipolar cell; DUCHENNE MUSCULAR-DYSTROPHY; STATIONARY NIGHT BLINDNESS; BRIGHT-FLASH ELECTRORETINOGRAM; LIGHT RESPONSE; BIPOLAR CELLS; FUNCTIONAL ABNORMALITIES; SYNAPTIC-TRANSMISSION; VASCULAR DEVELOPMENT; SIGNAL-TRANSDUCTION; ROD PHOTORECEPTORS;
D O I：
10.1007/s10633-013-9424-8
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
The b-wave is a major component of the electroretinogram that reflects the activity of depolarizing bipolar cells (DBCs). The b-wave is used diagnostically to identify patients with defects in DBC signaling or in transmission from photoreceptors to DBCs. In mouse models, an abnormal b-wave has been used to demonstrate a critical role of a particular protein in the release of glutamate from photoreceptor terminals, in establishing the structure of the photoreceptor-to-DBC synapse, in DBC signal transduction, and also in DBC development, survival, or metabolic support. The purpose of this review is to summarize these models and how they have advanced our understanding of outer retinal function.
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页码：77 / 89
页数：13
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