A practical synthesis of (S)-(+)-2-(6′-methoxyl-2-naphthyl) propionic acid

被引：0
|
作者：
Ma, HZ [1 ]
Wang, B [1 ]
Shi, QZ [1 ]
机构：
[1] NW Univ Xian, Dept Chem, ShaanXi Key Lab Physicoinorgan Chem, Xian 710068, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2002年 / 13卷 / 06期
关键词：
auxiliary; D-mannitol; enantioselective synthesis; one-pot; (S)-(+)-naproxen;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simplified procedure for enantioselective synthesis of (S)-(+)-2-(6'-methoxyl-2-naphthyl) propionic acid ((S)-(+)-naproxen), starting from (6-methoxy-a-naphthyl)-1-propanone, with D-mannitol as auxiliary catalyzed by SmCl(3) in one-pot is described. The yield is 87.5%(ee value 99%).
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页码：505 / 508
页数：4
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