Cytotoxic β-carbolines and cyclic peroxides from the palauan sponge Plakortis nigra

被引：63
|
作者：
Sandler, JS
Colin, PL
Hooper, JNA
Faulkner, DJ [1 ]
机构：
[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA
[2] Queensland Museum, Queensland Ctr Biodivers, Brisbane, Qld 4101, Australia
[3] Coral Reef Res Fdn, Koror, Palau
来源：
JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 09期
关键词：
D O I：
10.1021/np020228v
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Four beta-carbolines, plakortamines A-D, two cyclic peroxides, epiplakinic acids G and H, and two related gamma-lactones, (2S*,4R*)- and (2R*,4R*)-2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactones, were isolated from the deep-water sponge Plakortis nigra from Palau. The structures of the eight now metabolites were elucidated by interpretation of spectroscopic data, Most of the metabolites inhibited the HCT-116 human colon tumor cell line.
引用
收藏
页码：1258 / 1261
页数：4
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