Cytotoxic β-carbolines and cyclic peroxides from the palauan sponge Plakortis nigra

被引：63

作者：

Sandler, JS

Colin, PL

Hooper, JNA

Faulkner, DJ ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, La Jolla, CA 92093 USA

[2] Queensland Museum, Queensland Ctr Biodivers, Brisbane, Qld 4101, Australia

[3] Coral Reef Res Fdn, Koror, Palau

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 09期

关键词：

D O I：

10.1021/np020228v

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four beta-carbolines, plakortamines A-D, two cyclic peroxides, epiplakinic acids G and H, and two related gamma-lactones, (2S*,4R*)- and (2R*,4R*)-2,4-dimethyl-4-hydroxy-16-phenylhexadecanoic acid 1,4-lactones, were isolated from the deep-water sponge Plakortis nigra from Palau. The structures of the eight now metabolites were elucidated by interpretation of spectroscopic data, Most of the metabolites inhibited the HCT-116 human colon tumor cell line.

引用

页码：1258 / 1261

页数：4

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