MiR-520c-3p alleviates LPS-induced A549 cell and mice lung injury via targeting NLRC5

被引：4

作者：

Li, Na-Na ^{[1
]}

Cao, Tao ^{[2
]}

Yu, Fei ^{[3
]}

Luo, Lian ^{[1
]}

Liu, Ping ^{[4
]}

机构：

[1] Peoples Hosp Changshou Chongqing, Dept Pharm, Chongqiong, Peoples R China

[2] Nanjing Zhongshan Med Technol Translat Res Inst, Nanjing, Peoples R China

[3] Peoples Hosp Changshou Chongqing, Med Dept, Chongqiong, Peoples R China

[4] Peoples Hosp Changshou Chongqing, Pulm & Crit Care Med, Chongqiong 401220, Peoples R China

来源：

PHARMAZIE | 2020年 / 75卷 / 06期

关键词：

D O I：

10.1692/ph.2020.0355

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

MicroRNAs (miRNAs) play important roles in the progression of acute lung injury (ALI). So far, little is known about the role of miR-520c-3p in ALI. In this study, the mechanism of the occurrence and development of ALI was explored. We firstly found that miR-520c-3p could inhibit the expression of NLRC5. A549 cells were treated with lipopolysaccharide (LPS) in vitro to simulate ALI cells and inducing ALI model mice. Moreover, miR-520c-3p overexpression enhanced the viability of damaged cells, inhibited LPS-induced apoptosis, and decreased LPS-induced IL-1 beta, IL-6 and TNF-alpha. In addition, the NLRC5 was a direct target of miR-520c-3p. And NLRC5 partially aggravated inflammation injury. In conclusion, miR-520c-3p alleviates LPS-induced inflammatory injury via regulating NLRC5.

引用

页码：275 / 278

页数：4

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