Advances in quantum dot-based biosensors for DNA-modifying enzymes assay

被引：41
|
作者：
Zhang, Qian [1 ]
Zhang, Xinyi [2 ]
Ma, Fei [3 ]
Zhang, Chun-yang [1 ]
机构：
[1] Shandong Normal Univ, Coll Chem Chem Engn & Mat Sci, Jinan 250014, Peoples R China
[2] Guangdong Pharmaceut Univ, Sch Chem & Chem Engn, Zhongshan 528458, Peoples R China
[3] Southeast Univ, Sch Chem & Chem Engn, Nanjing 211189, Peoples R China
来源：
COORDINATION CHEMISTRY REVIEWS | 2022年 / 469卷
关键词：
Quantum dots; Biosensors; DNA glycosylase; DNA methyltransferase; Alkaline phosphatase; Telomerase; RESONANCE ENERGY-TRANSFER; T4 POLYNUCLEOTIDE KINASE; ALKALINE-PHOSPHATASE ACTIVITY; HIGHLY SENSITIVE DETECTION; TELOMERASE ACTIVITY; EXCISION-REPAIR; THYMINE DNA; MULTICOLOR COLOCALIZATION; ULTRASENSITIVE DETECTION; GLYCOSYLASE DOMAIN;
D O I：
10.1016/j.ccr.2022.214674
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
DNA-modifying enzymes participate in various genetic functions (e.g., DNA replication, repairing, and recombination) through alternating certain DNA sequence, and the malfunction of DNA-modifying enzymes may disturb the normal genetic functions and consequently causes diverse human diseases. DNA-modifying enzymes may serve as the valuable diagnosis biomarkers and therapeutic targets, and the detection of DNA-modifying enzymes is essential to fundamental research, anticancer-drug discovery, and clinical diagnosis. Quantum dots (QDs) have many excellent electronic and optical characteristics, facilitating their biosensing and bioimaging applications. We review the development of QDs-based biosensors for DNA-modifying enzyme assays, and discuss current challenges and future directions in this field.(c) 2022 Elsevier B.V. All rights reserved.
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收藏
页数：17
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