Diffusion tensor MR imaging of the brain

Diffusion tensor MR imaging is a technique that provides details on tissue microstructure and organization well beyond the usual image resolution. With diffusion tensor MR imaging, diffusion anisotropy can be quantified and subtle white changes not normally seen on conventional MRI can be detected. The purpose of this article is to review the current application of diffusion tensor MR imaging for the study of the brain, including normal aging, Alzheimer's disease, neurophyschiatric disorders, strokes, multiple sclerosis, brain tumors and intractable seizures.