Anticonvulsant and sedative-hypnotic activities of N-substituted isatin semicarbazones

被引：0
|
作者：
Pandeya, SN [1 ]
Smitha, S
Stables, JP
机构：
[1] Banaras Hindu Univ, Inst Technol, Dept Pharmaceut, Varanasi 221005, Uttar Pradesh, India
[2] Epilepsy Branch, Preclin Pharmacol Sect, NIH, Bethesda, MD USA
来源：
ARCHIV DER PHARMAZIE | 2002年 / 335卷 / 04期
关键词：
epilepsy; anticonvulsants; sedative-hypnotic activity; isatin semicarbazones;
D O I：
10.1002/1521-4184(200204)335:4<129::AID-ARDP129>3.0.CO;2-W
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of N-methyl/acetyl, 5-(un)-substituted isatin-3-semicarbazones were screened for anticonvulsant and sedative-hypnotic activities. The results revealed that protection was obtained in all the screens i.e., MES, scPTZ, and scSTY. Compounds 2, 4, 6, 10 but not 1 and 3 showed low neurotoxicity when compared to clinically used drugs. Compounds 5, 7, 8 and 9 were completely non-toxic. Compound 6 showed good activity in the rat oral MES screen. Among all the compounds, 3 and 6 emerged as the most active compounds as indicated by the protection they exhibit in MES, scSTY, and scPTZ screens. All the compounds showed significant sedative-hypnotic activity.
引用
收藏
页码：129 / 134
页数：6
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