Synthesis and protozoocidal activity of new 1,4-naphthoquinones

被引：0
|
作者：
Danoun, S
Baziard-Mouysset, G
Stigliani, JL
Ané-Margail, M
Payard, M
Léger, JM
Canron, X
Vial, H
Loiseau, PM
Bories, C
Récoché, C
机构：
[1] Fac Pharm, Lab Chim Pharmaceut, F-31062 Toulouse, France
[2] UFR Pharm, Lab Chim Analyt & Cristallog, F-33076 Bordeaux, France
[3] Dept Biol Sante, F-34095 Montpellier, France
[4] Fac Pharm, Parasitol Lab, F-92290 Chatenay Malabry, France
来源：
HETEROCYCLIC COMMUNICATIONS | 1999年 / 5卷 / 04期
关键词：
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Four naphthoquinones were submitted to the action of diazomethane. The structure of the nine adducts, of which four were original, was determined. The protozoocidal activity of these compounds was evaluated in vitro against Plasmodium falciparum, Leishmania donovani, Trypanosoma brucei and Trichomonas vaginalis. The 2-methoxy-naphthoquinone <(3a)under bar> exhibited some activity and was more potent against these four protozoa than the reference drugs. The 2-methoxynaphthoquinone <(4a)under bar> showed more activity than chloroquine towards Plasmodium falciparum.
引用
收藏
页码：343 / 348
页数：6
相关论文
共 50 条
  • [21] Synthesis and preliminary pharmacological evaluation of new (±) 1,4-naphthoquinones structurally related to lapachol
    da Silva, AJM
    Buarque, CD
    Brito, FV
    Aurelian, L
    Macedo, LF
    Malkas, LH
    Hickey, RJ
    Lopes, DVS
    Noël, F
    Murakami, YLB
    Silva, NMV
    Melo, PA
    Caruso, RRB
    Castro, NG
    Costa, PRR
    BIOORGANIC & MEDICINAL CHEMISTRY, 2002, 10 (08) : 2731 - 2738
  • [22] Synthesis of New 6,7(N,O)-Heterocyclic 1,4-Naphthoquinones
    Buchkevych, Iryna
    Kurka, Mariia
    Krvavych, Anna
    Monka, Natalija
    Novikov, Volodymyr
    Lubenets, Vira
    BIOINTERFACE RESEARCH IN APPLIED CHEMISTRY, 2021, 11 (06): : 13903 - 13910
  • [23] Green synthesis of thiophenyl-1,4-naphthoquinones
    Kanodia, Saraswati
    Thapliyal, Prakash Chander
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 2012, 89 (06) : 833 - 836
  • [24] Electrooxidative dehydrogenative coupling of 1,4-naphthoquinones with amines: Facile access to 2-amino-1,4-naphthoquinones
    Wu, Xi
    Zhao, Xiao-Jing
    Zhang, Lizhu
    Li, Ganpeng
    He, Yonghui
    TETRAHEDRON LETTERS, 2022, 112
  • [25] STUDIES ON THE ANALGETIC EFFECT OF 1,4-NAPHTHOQUINONES
    CHEMNITIUS, KH
    HOFMANN, H
    ARZNEIMITTEL-FORSCHUNG-DRUG RESEARCH, 1958, 8 (01): : 25 - 28
  • [26] DEGRADATION OF 1,4-NAPHTHOQUINONES BY PSEUDOMONAS PUTIDA
    MULLER, U
    LINGENS, F
    BIOLOGICAL CHEMISTRY HOPPE-SEYLER, 1988, 369 (09): : 1031 - 1043
  • [27] Synthesis of Fluorine-Containing Poly(phenylamino)-1,4-naphthoquinones
    N. M. Troshkova
    L. I. Goryunov
    V. D. Shteingarts
    Russian Journal of Organic Chemistry, 2010, 46 : 1585 - 1587
  • [28] Activity of New Synthetic (2-Chloroethylthio)-1,4-naphthoquinones in Prostate Cancer Cells
    Dyshlovoy, Sergey A.
    Pelageev, Dmitry N.
    Jakob, Lea S.
    Borisova, Ksenia L.
    Hauschild, Jessica
    Busenbender, Tobias
    Kaune, Moritz
    Khmelevskaya, Ekaterina A.
    Graefen, Markus
    Bokemeyer, Carsten
    Anufriev, Victor Ph
    von Amsberg, Gunhild
    PHARMACEUTICALS, 2021, 14 (10)
  • [29] THE REACTION OF 1,4-NAPHTHOQUINONES WITH SODIUM THIOSULFATE
    ARAI, G
    NIPPON KAGAKU KAISHI, 1983, (04) : 551 - 555
  • [30] AN IMPROVED SYNTHESIS OF 1,4-BENZOQUINONES AND 1,4-NAPHTHOQUINONES BEARING ACTIVE SUBSTITUENTS
    SYPER, L
    KLOC, K
    MLOCHOWSKI, J
    JOURNAL FUR PRAKTISCHE CHEMIE, 1985, 327 (05): : 808 - 822
12345