Whole genome sequencing analysis of multidrug-resistant tuberculosis in Singapore, 2006-2018

被引：10

作者：

Chee, Cynthia B. E. ^{[1
]}

Lim, Leo K. Y. ^{[1
]}

Ong, Rick T. H. ^{[2
]}

Sng, Li Hwei ^{[3
]}

Hsu, Li Yang ^{[2
]}

Lee, Vernon J. M. ^{[4
]}

Wang, Yee Tang ^{[1
]}

机构：

[1] Tan Tock Seng Hosp, TB Control Unit, Singapore, Singapore

[2] Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore

[3] Singapore Gen Hosp, Singapore, Singapore

[4] Minist Hlth, Singapore, Singapore

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2021年 / 40卷 / 05期

关键词：

Multidrug-resistant; Tuberculosis; Whole genome sequencing; MIRU-VNTR; Spoligotyping; Singapore; MYCOBACTERIUM-TUBERCULOSIS; TRANSMISSION; CLUSTER;

D O I：

10.1007/s10096-020-04100-6

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

There were 290 multidrug-resistant (MDR)-TB cases diagnosed in Singapore from 2006 to 2018. Eighty-one percent were foreign-born. Spoligotyping and MIRU-VNTR methods identified 108 patients in 24 clusters. The Beijing spoligotype accounted for 22 clusters. Whole genome sequencing (WGS) analysis reduced the number of clustered patients and clusters to 43 and nine respectively. One MIRU cluster was redefined into three WGS clusters. All the clusters had foreign-born source cases. Forty percent of local-born, versus 9% of foreign-born, MDR-TB cases belonged to WGS clusters. WGS more accurately elucidated potential MDR-TB transmission which was overestimated by conventional genotyping methods in Singapore.

引用

页码：1079 / 1083

页数：5

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