In Vivo CRISPR-Cas Genome Editing with No Detectable Off-Target Mutations

被引：0

作者：

Bobbin, Maggie L. ^{[1
,2
]}

Akcakaya, Pinar ^{[3
]}

Guo, Jimmy ^{[1
,2
]}

Fellows, Mick ^{[4
]}

Porritt, Michelle ^{[3
]}

Firth, Mike ^{[3
]}

Carreras, Alba ^{[3
]}

Baccega, Tania ^{[3
]}

Tsai, Shengdar ^{[1
,2
]}

Nguyen, Nhu T. ^{[1
,2
]}

Seeliger, Frank ^{[5
]}

Bjursell, Mikael ^{[3
]}

Nitsch, Roberto ^{[4
]}

Lopez, Jose M. ^{[1
,2
]}

Clement, Kendell ^{[1
,2
]}

Garcia, Sara P. ^{[1
,2
]}

Hsu, Jonathan Y. ^{[1
,2
]}

Pinello, Luca ^{[1
,2
]}

Aryee, Martin ^{[1
,2
]}

Mayr, Lorenz M. ^{[3
]}

Bohlooly-Y, Mohammad ^{[3
]}

Maresca, Marcello ^{[3
]}

Joung, J. Keith ^{[1
,2
]}

机构：

[1] MGH, Pathol, Boston, MA USA

[2] Harvard Med Sch, Pathol, Boston, MA USA

[3] AstraZeneca, IMED Biotech Unit, Discovery Biol, Discovery Sci, Gothenburg, Sweden

[4] AstraZeneca, IMED Biotech Unit, New Drug Modal Drug Safety & Metab, Cambridge, England

[5] AstraZeneca, IMED Biotech Unit, Pathol Sci Drug Safety & Metab, Gothenburg, Sweden

来源：

MOLECULAR THERAPY | 2018年 / 26卷 / 05期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

引用

页码：22 / 23

页数：2

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Guo, Jimmy A.
Malagon-Lopez, Jose
Clement, Kendell
Garcia, Sara P.
Fellows, Mick D.
Porritt, Michelle J.
Firth, Mike A.
Carreras, Alba
Baccega, Tania
Seeliger, Frank
Bjursell, Mikael
Tsai, Shengdar Q.
Nguyen, Nhu T.
Nitsch, Roberto
Mayr, Lorenz M.
Pinello, Luca
Bohlool-Y, Mohammad
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Maresca, Marcello
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[J]. NATURE, 2018, 561 (7723) : 416 - +
[2] In vivo CRISPR editing with no detectable genome-wide off-target mutations
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