Early-onset Alzheimer disease - When is genetic testing appropriate?

被引：12

作者：

Goldman, JS ^{[1
]}

Hou, CE ^{[1
]}

机构：

[1] Univ Calif San Francisco, Memory & Aging Ctr, San Francisco, CA 94143 USA

来源：

ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2004年 / 18卷 / 02期

关键词：

genetic testing; early-onset AD; presenilin; 1; ethical issues;

D O I：

10.1097/01.wad.0000126616.77653.71

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer disease (AD) is a neurodegenerative disease that is currently not preventable or curable. Early-onset AD can be due to mutations in several autosomal dominant genes. Clinical testing is available for presenilin I (PSI), which is the most common of these genes. However, many practical and ethical issues must be considered before ordering this test for patients with early-onset AD. In this paper, we present a case that demonstrates the complexities of genetic testing for early-onset AD.

引用

页码：65 / 67

页数：3

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