Anti-tubular basement membrane antibodies and giant cell formation in a model of chronic renal allograft rejection

被引:1
|
作者
Joosten, SA
Benediktsson, H
Borrias, MC
Van Ham, V
Van Dixhoorn, MGA
Van Kooten, C
Paul, LC
机构
[1] Leiden Univ, Med Ctr, Dept Nephrol, NL-2333 ZA Leiden, Netherlands
[2] Univ Calgary, Dept Pathol & Lab Med, Calgary, AB, Canada
关键词
D O I
10.1097/01.TP.0000122189.53240.B9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. In the Fisher (F344)-to-Lewis (LEW) kidney transplantation (Tx) model of chronic rejection, antibodies reactive with tubular basement membranes have been found. We investigated whether giant cells, typical for a granulomatous inflammatory reaction, can be found during allograft rejection. Methods. F344-to-LEW renal Txs were performed, and kidneys were removed at various time points. Kidneys were analyzed by histology and immunohistochemistry. Interferon-gamma levels were measured by reverse-transcriptase polymerase chain reaction. Results. Multinucleated Langhans'-type giant cells were found in F344 allografts at days 21 and 30 and disappeared thereafter. Giant cells were not observed in LEW allografts. The giant cells were ED1, OX-43, and major histocompatibility complex class 11 positive. All grafts showed transient expression of interferon-gamma, peaking at days 7 to 14 post-Tx. Conclusion. Granulomatous inflammation with giant cell formation occurs in the F344-to-LEW model and may represent an alloimmune response against tissue-specific antigens.
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收藏
页码:1295 / 1297
页数:3
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