EFFICIENT ONE-POT SYNTHESIS OF SUBSTITUTED OXAZOLES FROM 3-TRIMETHYLSILYLPROPARGYLIC ALCOHOLS AND AMIDES BY GOLD-CATALYZED SUBSTITUTION FOLLOWED BY CYCLOISOMERIZATION

被引：7

作者：

Morita, Nobuyoshi ^{[1
]}

Sano, Aoi ^{[1
]}

Sone, Ayako ^{[1
]}

Aonuma, Shino ^{[1
]}

Matsunaga, Arisa ^{[1
]}

Hashimoto, Yoshimitsu ^{[1
]}

Tamura, Osamu ^{[1
]}

机构：

[1] Showa Pharmaceut Univ, Machida, Tokyo 1948543, Japan

来源：

HETEROCYCLES | 2018年 / 97卷 / 02期

关键词：

PROPARGYLIC ALCOHOLS; GOLD(I)/(III)-CATALYZED SYNTHESIS; FUNCTIONALIZED OXAZOLES; MEDIATED SYNTHESIS; CYCLIZATION; SEQUENCE;

D O I：

10.3987/COM-18-S(T)81

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Trimethylsilylpropargylic alcohols 1, on treatment with amides 2 in the presence of catalytic amounts of cationic gold(III), underwent propargylic substitution followed by cycloisomerization, in which the key feature is the beta-cation-stabilizing effect of the silicon atom of 1.

引用

页码：719 / 728

页数：10

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