New approaches towards the synthesis of alkenes using the Horner-Wadsworth-Emmons (HWE) reaction as the key step

被引：1
|
作者：
Bodman, K [1 ]
Has-Becker, S [1 ]
Reiser, O [1 ]
机构：
[1] Univ Regensburg, Dept Organ Chem, D-93053 Regensburg, Germany
来源：
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 1999年 / 144卷
关键词：
Horner-Wadsworth-Emmons reaction; Heck reaction; high pressure palladium; alkenes;
D O I：
10.1080/10426509908546210
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Leading from our work in asymmetric alkene synthesis it was discovered that the alkenylatio of aldehydes with phosphonates proceeds smoothly at room temperature in the absence of Lewis acidusing triethylamine as the base if the reaction is carried out at a pressure of 8 kbar. Based on this protoco a new domino process was developed, combining the HWE reaction with a Heck coupling, thus allowing the one pot synthesis of trisubstituted alkenes.
引用
收藏
页码：173 / 176
页数：4
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