A new micro/nanoencapsulated porphyrin formulation for PDT treatment

被引：37
|
作者：
Deda, Daiana K. [1 ]
Uchoa, Adjaci F. [1 ]
Carita, Eduardo [1 ]
Baptista, Mauricio S. [1 ]
Toma, Henrique E. [1 ]
Araki, Koiti [1 ]
机构：
[1] Univ Sao Paulo, Inst Chem, BR-05508000 Sao Paulo, Brazil
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2009年 / 376卷 / 1-2期
基金：
巴西圣保罗研究基金会;
关键词：
Cationic porphyrin; Polymeric encapsulation; PDT; HeLa cells; CATIONIC TETRARUTHENATED PORPHYRIN; N-CONFUSED PORPHYRIN; OF-THE-ART; PHOTODYNAMIC THERAPY; PHOTOPHYSICAL PROPERTIES; PROCESSING PARAMETERS; NANOPARTICLES; DELIVERY; PHOTOSENSITIZERS; COACERVATION;
D O I：
10.1016/j.ijpharm.2009.04.024
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The highly hydrophobic 5,10,15-triphenyl-20-(3-N-methylpyridinium-yl)porphyrin(3MMe)cationic species was synthesized, characterized and encapsulated in marine atelocollagen/xanthane gum microcapsules by the coacervation method. Further reduction in the capsule size, from several microns down to about 300-400 nm, was carried out successfully by ultrasonic processing in the presence of up to 1.6% Tween 20 surfactant, without affecting the distribution of 3MMe in the oily core. The resulting creamlike product exhibited enhanced photodynamic activity but negligible cytotoxicity towards HeLa cells. The polymeric micro/nanocapsule formulation was found to be about 4 times more phototoxic than the respective phosphatidylcholine lipidic emulsion, demonstrating high potentiality for photodynamic therapy applications. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：76 / 83
页数：8
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