Antrocarines A-F, antiplasmodial ergostane steroids from the stem bark of Antrocaryon klaineanum

被引：11
|
作者：
Douanla, Pascal D. [1 ]
Tabopda, Turibio Kuiate [1 ]
Tchinda, Alembert T. [2 ]
Cieckiewicz, Ewa [3 ]
Frederich, Michel [3 ]
Boyom, Fabrice Fekam [4 ]
Tsabang, Nole [2 ]
Yeboah, Samuel [5 ]
Nkengfack, Augustin E. [1 ]
Tchuendem, Marguerite Hortence K. [1 ]
机构：
[1] Univ Yaounde I, Fac Sci, Dept Organ Chem, Yaounde, Cameroon
[2] Inst Med Res & Med Plant Studies, Lab Phytochem, IMPM, Yaounde, Cameroon
[3] Univ Liege, Lab Pharmacognosie, Ctr Interfac Rech Medicament CIRM, Dept Pharm, B-4000 Liege, Belgium
[4] Univ Yaounde I, Fac Sci, Dept Biochem, Yaounde, Cameroon
[5] Univ Botswana, Dept Chem, Gaborone, Botswana
来源：
PHYTOCHEMISTRY | 2015年 / 117卷
关键词：
Antrocaryon klaineanum; Anacardiaceae; Ergostane steroids; Antiplasmodial activities; MEDICINAL-PLANTS; ANTIBACTERIAL ACTIVITY; ENTANDROPHRAGMA-UTILE; CYTOTOXIC ACTIVITY; STRYCHNOS-ICAJA; ALKALOIDS; INHIBITOR;
D O I：
10.1016/j.phytochem.2015.07.011
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
During a study on the chemistry and biological activity of Antrocaryon klaineanum Pierre, six new sterols including 4,24(28)-ergostadiene-6 alpha,7 alpha-diol (1), 6 alpha-methoxy-4,24(28)-ergostadiene-7 alpha,20S-diol (2), 6 alpha-methoxy-4,24(28)-ergostadien-7 alpha-ol (3), 20S-hydroxy-24(28)-ergosten-3-one (4), 7 alpha-hydroxy-4,24(28)-ergostadien-3-one (5), and 24(28)-ergostene-3 beta,6 alpha-diol (6) were characterized by physical and spectroscopic means. The known steroids 7 and 8 were also isolated. The crude extract and the isolated compounds were evaluated for their ability to inhibit the 3D7 strain of Plasmodium falciparum. Compounds 2, 3, and 8 showed potent activity while that of the crude extract was moderate. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：521 / 526
页数：6
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