Adalimumab therapy in rheumatoid arthritis

被引：35
|
作者：
Keystone, E
Haraoui, B
机构：
[1] Univ Toronto, Div Adv Therapeut, Rebecca MacDonald Ctr Arthrit & Autoimmune Dis, Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada
[2] Inst Rheumatol Montreal, Montreal, PQ H2L 1S6, Canada
来源：
RHEUMATIC DISEASE CLINICS OF NORTH AMERICA | 2004年 / 30卷 / 02期
关键词：
D O I：
10.1016/j.rdc.2004.02.004
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Adalimumab is a recombinant human immunoglobulin G1 monoclonal antibody that is specific for human tumor necrosis factor. Based on the data presented in this article, adalimumab administered alone or in patients partially responsive to methotrexate exhibits a rapid onset of action, provides a substantial reduction in signs and symptoms, and results in an improvement in physical function and health-related quality of life. Adalimumab has been demonstrated to inhibit progression of structural joint damage in patients who have long-standing rheumatoid arthritis. Taken together, the data support adalimumab as a new therapeutic option for patients with moderate to severe rheumatoid arthritis.
引用
收藏
页码：349 / +
页数：17
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