Pyrazole containing natural products: Synthetic preview and biological significance

被引：523

作者：

Kumar, Vinod ^{[1
]}

Kaur, Kamalneet ^{[1
]}

Gupta, Girish Kumar ^{[2
]}

Sharma, Anil Kumar ^{[3
]}

机构：

[1] Maharishi Markandeshwar Univ, Dept Chem, Ambala 133207, Haryana, India

[2] Maharishi Markandeshwar Univ, Dept Pharmaceut Chem, Ambala 133207, Haryana, India

[3] Maharishi Markandeshwar Univ, Dept Biotechnol, Ambala 133207, Haryana, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 69卷

关键词：

Pyrazoles; Natural products; Isolation; Pharmacological activities; FORMYCIN-B; AMINO-ACIDS; NOSTOCINE-A; ANTIBACTERIAL ACTIVITY; ANTIBIOTICS FORMYCIN; RADICAL CYCLIZATION; C-NUCLEOSIDE; ALKALOIDS; ANALOGS; BIOSYNTHESIS;

D O I：

10.1016/j.ejmech.2013.08.053

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A large number of structurally diverse natural compounds containing azole nucleus constitute an important class of biologically active heterocycles that are gaining more attention in the field of medicinal chemistry. Among azoles, pyrazoles are rarely found in nature probably due to difficulty in the formation of N N bond by living organisms. However, they exhibit numerous biological activities, including anti-diabetic, antiviral, anticancer, anti-inflammatory, antibacterial and antifungal activities. The present review is an attempt to understand the chemistry along with medicinal importance of pyrazole containing natural products reported till date which would certainly help the scientific community to bring further developments in the isolation and synthetic methodologies for pyrazole based novel bioactive compounds. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：735 / 753

页数：19

共 50 条

[31] Recent developments in synthetic chemistry and biological activities of pyrazole derivatives
Muhammad Faisal
Aamer Saeed
Sarwat Hussain
Parsa Dar
Fayaz Ali Larik
Journal of Chemical Sciences, 2019, 131
[32] SYNTHETIC STUDIES ON GLYCOCONJUGATES OF BIOLOGICAL SIGNIFICANCE
OGAWA, T
NUNOMURA, S
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1989, 197 : 17 - CARB
[33] A close look into the biological and synthetic aspects of fused pyrazole derivatives
Li, Mei-Mei
Huang, Hui
Pu, Yiru
Tian, Wanrong
Deng, Yun
Lu, Jun
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 243
[34] Isolation, biological activity, biosynthesis and synthetic studies towards the rubromycin family of natural products
Atkinson, Darcy J.
Brimble, Margaret A.
NATURAL PRODUCT REPORTS, 2015, 32 (06) : 811 - 840
[35] Synthetic analogs of indole-containing natural products as inhibitors of sortase A and isocitrate lyase
Lee, Yeon-Ju
Han, Yu-Ri
Park, Wanki
Nam, Seo-Hee
Oh, Ki-Bong
Lee, Hyi-Seung
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (23) : 6882 - 6885
[36] Synthetic Strategies toward Natural Products Containing Contiguous Stereogenic Quaternary Carbon Atoms
Bueschleb, Martin
Dorich, Stephane
Hanessian, Stephen
Tao, Daniel
Schenthal, Kyle B.
Overman, Larry E.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 55 (13) : 4156 - 4186
[37] Natural Products Containing Oxygen Heterocycles-Synthetic Advances Between 1990 and 2015
Cossy, Janine
Guerinot, Amandine
HETEROCYCLIC CHEMISTRY IN THE 21ST CENTURY: A TRIBUTE TO ALAN KATRITZKY, 2016, 119 : 107 - 142
[38] Synthetic studies toward 1,4-diol containing natural products.
Hanson, PR
Pierson, DA
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1998, 216 : U462 - U462
[39] Natural products with biological activity
Goldstein, Mindy S.
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2005, 230 : U4294 - U4295
[40] Biological Activities of Natural Products
Ekiert, Halina Maria
Szopa, Agnieszka
MOLECULES, 2020, 25 (23):

← 1 2 3 4 5 →