Cyclization of 2-benzoylamino-N-methyl-thiobenzamides to 3-methyl-2-phenylquinazolin-4-thiones

被引：11
|
作者：
Hanusek, Jiri
Rosa, Pavel
Drabina, Pavel
Sedlak, Milos
机构：
[1] Univ Pardubice, Fac Chem Technol, Dept Organ Chem, Pardubice 53210, Czech Republic
[2] ANIVEG CZ Sro, Lovosice 41002, Czech Republic
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 05期
关键词：
D O I：
10.1002/jhet.5570430521
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Acylation of 2-amino-N-methyl-thiobenzamide with substituted benzoyl chlorides has been used to synthesize the corresponding 2-benzoylamino-N-methylthiobenzamides. Subsequent sodium methoxide-catalyzed ring closure gives the corresponding 3-methyl-2-phenylquinazoline-4-thiones. These compounds were characterized by means of their H-1- and C-13-NMR spectra. The kinetics of the cyclization reaction has been followed with UV-VIS spectroscopy at 100 degrees C in methanolic solutions of sodium methoxide.
引用
收藏
页码：1281 / 1285
页数：5
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