Cyclization of 2-benzoylamino-N-methyl-thiobenzamides to 3-methyl-2-phenylquinazolin-4-thiones

被引：11

作者：

Hanusek, Jiri

Rosa, Pavel

Drabina, Pavel

Sedlak, Milos

机构：

[1] Univ Pardubice, Fac Chem Technol, Dept Organ Chem, Pardubice 53210, Czech Republic

[2] ANIVEG CZ Sro, Lovosice 41002, Czech Republic

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 05期

关键词：

D O I：

10.1002/jhet.5570430521

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Acylation of 2-amino-N-methyl-thiobenzamide with substituted benzoyl chlorides has been used to synthesize the corresponding 2-benzoylamino-N-methylthiobenzamides. Subsequent sodium methoxide-catalyzed ring closure gives the corresponding 3-methyl-2-phenylquinazoline-4-thiones. These compounds were characterized by means of their H-1- and C-13-NMR spectra. The kinetics of the cyclization reaction has been followed with UV-VIS spectroscopy at 100 degrees C in methanolic solutions of sodium methoxide.

引用

页码：1281 / 1285

页数：5

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