Separation of NADH-fumarate reductase and succinate dehydrogenase activities in Trypanosoma cruzi

被引：0
|
作者：
Christmas, PB [1 ]
Turrens, JF [1 ]
机构：
[1] Univ S Alabama, Dept Biomed Sci, Coll Allied Hlth Profess, Mobile, AL 36688 USA
来源：
FEMS MICROBIOLOGY LETTERS | 2000年 / 183卷 / 02期
关键词：
Trypanosoma cruzi; NADH-fumarate reductase; succinate dehydrogenase; electron transfer; mitochondria; metabolism;
D O I：
10.1016/S0378-1097(99)00646-1
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A recent review suggested that the activity of NADH-fumarate reductase from trypanosomatids could be catalyzed by succinate dehydrogenase working in reverse (Tielens and van Hellemond, Parasitol. Today 14, 265-271, 1999). The results reported in this study demonstrate that the two activities can easily be separated without any loss in either activity, suggesting that fumarate reductase and succinate dehydrogenase are separate enzymes. (C) 2000 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.
引用
收藏
页码：225 / 228
页数：4
相关论文
共 50 条
  • [31] Sartorypyrone D: a new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897
    Kaifuchi, Satoru
    Mori, Mihoko
    Nonaka, Kenichi
    Masuma, Rokuro
    Omura, Satoshi
    Shiomi, Kazuro
    JOURNAL OF ANTIBIOTICS, 2015, 68 (06): : 403 - 405
  • [32] Paecilaminol, a New NADH-Fumarate Reductase Inhibitor, Produced by Paecilomyces sp. FKI-0550
    Hideaki Ui
    Kazuro Shiomi
    Hideaki Suzuki
    Hiroko Hatano
    Hiromi Morimoto
    Yuichi Yamaguchi
    Rokuro Masuma
    Kimitoshi Sakamoto
    Kiyoshi Kita
    Hideto Miyoshi
    Hiroshi Tomoda
    Haruo Tanaka
    Satoshi Ōmura
    The Journal of Antibiotics, 2006, 59 : 591 - 596
  • [33] Sartorypyrone D: a new NADH-fumarate reductase inhibitor produced by Neosartorya fischeri FO-5897
    Satoru Kaifuchi
    Mihoko Mori
    Kenichi Nonaka
    Rokuro Masuma
    Satoshi Ōmura
    Kazuro Shiomi
    The Journal of Antibiotics, 2015, 68 : 403 - 405
  • [34] Ukulactones A and B, new NADH-fumarate reductase inhibitors produced by Penicillium sp FKI-3389
    Mori, Mihoko
    Morimoto, Hiromi
    Kim, Yong-Pil
    Ui, Hideaki
    Nonaka, Kenichi
    Masuma, Rokuro
    Sakamoto, Kimitoshi
    Kita, Kiyoshi
    Tomoda, Hiroshi
    Shiomi, Kazuro
    Omura, Satoshi
    TETRAHEDRON, 2011, 67 (35) : 6582 - 6586
  • [35] SUCCINATE-DCPIP AND NADH-FUMARATE OXIDOREDUCTASES IN FRESH-WATER SNAILS SUSCEPTIBLE AND NONSUSCEPTIBLE TO SCHISTOSOMA INFECTION
    NABIH, I
    ELANSARY, A
    CELLULAR AND MOLECULAR BIOLOGY, 1992, 38 (02) : 131 - 134
  • [36] Ukulactone C, a new NADH-fumarate reductase inhibitor produced by Talaromyces sp FKI-6713
    Kaifuchi, Satoru
    Mori, Mihoko
    Nonaka, Kenichi
    Masuma, Rokuro
    Omura, Satoshi
    Shiomi, Kazuro
    JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY, 2015, 61 (02): : 57 - 62
  • [37] Paecilaminol, a new NADH-fumarate reductase inhibitor, produced by Paecilomyces sp. FKI-0550
    Ui, Hideaki
    Shiomi, Kazuro
    Suzuki, Hideaki
    Hatano, Hiroko
    Morimoto, Hiromi
    Yamaguchi, Yuichi
    Masuma, Rokuro
    Sakamoto, Kimitoshi
    Kita, Kiyoshi
    Miyoshi, Hideto
    Tomoda, Hiroshi
    Tanaka, Haruo
    Omura, Satoshi
    JOURNAL OF ANTIBIOTICS, 2006, 59 (09): : 591 - 596
  • [38] Verticipyrone, a New NADH-fumarate Reductase Inhibitor, Produced by Verticillium sp. FKI-1083
    Hideaki Ui
    Kazuro Shiomi
    Hideaki Suzuki
    Hiroko Hatano
    Hiromi Morimoto
    Yuichi Yamaguchi
    Rokuro Masuma
    Toshiaki Sunazuka
    Hiroyuki Shimamura
    Kimitoshi Sakamoto
    Kiyoshi Kita
    Hideto Miyoshi
    Hiroshi Tomoda
    Satoshi Ōmura
    The Journal of Antibiotics, 2006, 59 : 785 - 790
  • [39] Total synthesis of nafuredin-γ, a γ-lactone related to nafuredin with selective inhibitory activity against NADH-fumarate reductase
    Nagamitsu, T
    Takano, D
    Shiomi, K
    Ui, H
    Yamaguchi, Y
    Masuma, R
    Harigaya, Y
    Kuwajima, I
    Omura, S
    TETRAHEDRON LETTERS, 2003, 44 (34) : 6441 - 6444
  • [40] The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments
    Tomitsuka, Eriko
    Kita, Kiyoshi
    Esumi, Hiroyasu
    MITOCHONDRIAL RESEARCH IN TRANSLATIONAL MEDICINE, 2010, 1201 : 44 - 49
12345