Wnt/beta-catenin signaling activates different target genes depending on stem/maturational status and HNF4α expression in hepatocellular carcinoma

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作者
Yamashita, Taro [1 ]
Honda, Masao [1 ]
Kaneko, Shuichi [1 ]
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[1] Kanazawa Univ, Grad Sch Med Sci, Dept Gastroenterol, Kanazawa, Ishikawa, Japan
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R57 [消化系及腹部疾病];
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1328
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页码:838A / 838A
页数:1
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  • [31] 5ASA blocks proliferation and expression of Wnt/beta-catenin target genes in epithelial cells after T cell activation.
    Manjali, JJ
    Dirisina, R
    Tang, YM
    Grimm, GR
    Jamal, Y
    Barrett, TA
    [J]. GASTROENTEROLOGY, 2005, 128 (04) : A197 - A197
  • [32] Wnt/beta-catenin signaling activates dUTP pyrophosphatase, a regulator of cellular dUTP levels, to prevent uracil misincorporation into DNA in human liver cancer stem cells
    Asahina, Yoshiro
    Yamashita, Taro
    Takatori, Hajime
    Oishi, Naoki
    Nio, Kouki
    Hayashi, Takehiro
    Nomura, Yoshimoto
    Hayashi, Tomoyuki
    Yoshida, Mariko
    Hashiba, Tomomi
    Suda, Tsuyoshi
    Honda, Masao
    Kaneko, Shuichi
    [J]. HEPATOLOGY, 2015, 62 : 554A - 554A
  • [33] Inhibition of Notch signaling causes progenitor-to-hepatocyte differentiation and regressions in a subset of hepatocellular carcinoma by controlling C/EBPα expression and HNF4α activity
    Seidel, Kerstin
    Piskol, Robert
    Thi Thu Thao Nguyen
    Cottonham, Charisa
    Merchant, Mark
    Siebel, Christian
    [J]. CANCER RESEARCH, 2022, 82 (12)
  • [34] DACH1, associated with a good prognosis and sensitivity to sorafenib in hepatocellular carcinoma, inhibits Wnt/beta-catenin signaling by suppressing the EGFR/ERK/FOXM1 axis
    Hu, Ling
    Wang, Dongxu
    Zhu, Hongbin
    Ma, Longteng
    Hu, Shiping
    Zhao, Xiangyang
    Ren, Shuyao
    Zhan, Sujuan
    He, Yuzhuo
    Li, Jiana
    [J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, 2021, 36 : 52 - 53
  • [35] miR-22 promotes stem cell traits via activating Wnt/beta-catenin signaling in cutaneous squamous cell carcinoma (vol 40, pg 5799, 2021)
    Yuan, Shukai
    Zhang, Peitao
    Wen, Liqi
    Jia, Shikai
    Wu, Yufan
    Zhang, Zhenlei
    Guan, Lizhao
    Yu, Zhengquan
    Zhao, Li
    [J]. ONCOGENE, 2022, 41 (11) : 1674 - 1676
  • [36] Beta-catenin accumulation in the progression of human hepatocarcinogenesis correlates with loss of E-cadherin and accumulation of p53, but not with expression of conventional WNT-1 target genes
    Prange, W
    Breuhahn, K
    Fischer, F
    Zilkens, C
    Pietsch, T
    Petmecky, K
    Eilers, R
    Dienes, HP
    Schirmacher, P
    [J]. JOURNAL OF PATHOLOGY, 2003, 201 (02): : 250 - 259
  • [37] Overexpression of hepatocyte nuclear factor 4α in human mesenchymal stem cells suppresses hepatocellular carcinoma development through Wnt/β-catenin signaling pathway downregulation
    Wu, Ning
    Zhang, Yu-Ling
    Wang, Hai-Tian
    Li, Da-Wei
    Dai, Hui-Juan
    Zhang, Qi-Qi
    Zhang, Jiang
    Ma, Yong
    Xia, Qiang
    Bian, Jian-Min
    Hang, Hua-Lian
    [J]. CANCER BIOLOGY & THERAPY, 2016, 17 (05) : 558 - 565
  • [38] FHL2 Mediates Dexamethasone-Induced Mesenchymal Stem Cell Osteogenic Differentiation by Activating Wnt/beta-Catenin Signaling and Runx2 Expression.
    Hamidouche, Z.
    Hay, E.
    Vaudin, P.
    Charbord, P.
    Marie, P. J.
    Fromigue, O.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2008, 23 : S385 - S385
  • [39] Wnt/beta-catenin signaling enhances hypoxia-induced epithelial-mesenchymal transition in hepatocellular carcinoma by increasing hif-1alpha activity and decreasing hypoxia-associated cell death
    Zhang, Qi
    Bai, Xueli
    Ma, Tao
    Chen, Wei
    Liu, Hao
    Hu, Qida
    Liang, Chao
    Xia, Xuefeng
    Yu, Xiazhen
    Zhi, Xiao
    Liang, Tingbo
    [J]. HEPATOLOGY, 2012, 56 : 614A - 614A
  • [40] Effect of human umbilical cord blood derived CD34+ hematopoietic stem cell on the expression of Wnt4 and P53 genes in a rat model of hepatocellular carcinoma
    Sherif, Rania Naiem
    Abdellatif, Hussein
    Hazem, Noha
    Ebrahim, Neven A.
    Saleh, Dalia
    Shiha, Gamal
    Eltahry, Huda
    Botros, Kamal G.
    Gabr, Omar M.
    [J]. TISSUE & CELL, 2018, 50 : 125 - 132