Brain Metastases in Non-Small-Cell Lung Cancer

被引：27
|
作者：
Dawe, David E. [1 ]
Greenspoon, Jeffrey N. [2 ]
Ellis, Peter M. [2 ]
机构：
[1] Univ Manitoba, Dept Internal Med, Winnipeg, MB R3E 0V9, Canada
[2] McMaster Univ, Dept Oncol, Hamilton, ON, Canada
来源：
CLINICAL LUNG CANCER | 2014年 / 15卷 / 04期
关键词：
Chemotherapy; Radiotherapy; Review; Stereotactic radiosurgery; Targeted agents; PROPHYLACTIC CRANIAL IRRADIATION; RANDOMIZED PHASE-III; GRADED PROGNOSTIC ASSESSMENT; NERVOUS-SYSTEM PROGRESSION; PARTITIONING ANALYSIS RPA; GAMMA-KNIFE SURGERY; RADIATION-THERAPY; STEREOTACTIC RADIOSURGERY; MOTEXAFIN GADOLINIUM; SINGLE METASTASES;
D O I：
10.1016/j.cllc.2014.04.008
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Up to 50% of patients with advanced non-small-cell lung cancer will develop brain metastases at some point during their illness. These metastases cause a substantial burden in morbidity and mortality, which has motivated research and technological innovation over the past 2 decades. Surgery, radiotherapy, and systemic therapies have each played a role in management, with the greatest changes associated with the popularization of stereotactic radiosurgery. In this review, the evidence behind each modality used in the management of brain metastases for non small-cell lung cancer patients is examined, and recommendations regarding the current standards of care and areas of future research focus are provided. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：249 / 257
页数：9
相关论文
共 50 条
  • [31] Checkpoint inhibitors in the treatment of brain metastases of non-small-cell lung cancer and melanoma
    Kourie, Hampig Raphael
    Kanaan, Hassan
    Awada, Gil
    Awada, Ahmad Hussein
    FUTURE ONCOLOGY, 2017, 13 (12) : 1097 - 1103
  • [32] Incidence of hippocampal metastases in non-small-cell lung cancer
    Ly, Sophia
    Lehman, Margot
    Liu, Howard
    Hukins, Craig
    Murphy, Michelle
    Dauth, Margaret
    Devine, Matthew S.
    Mai, Gang Tao
    JOURNAL OF MEDICAL IMAGING AND RADIATION ONCOLOGY, 2020, 64 (04) : 586 - 590
  • [33] Non-small-cell lung cancer with brain metastasis
    Lillehei, KO
    Simon, J
    Gaspar, L
    Damek, DM
    ONCOLOGY-NEW YORK, 2004, 18 (14): : 1725 - 1728
  • [34] Brain metastases: the need for a more tailored approach in non-small-cell lung cancer patients
    Martinez, Pablo
    Felip, Enriqueta
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2012, 14 (01): : 1 - 2
  • [35] A Prognostic Score for Brain Metastases of Non-small-cell Lung Cancer in the Era of Precision Medicine
    Hsu, Hua-Shai
    Hu, Sung-Lin
    Chien, Chun-Ru
    LUNG, 2019, 197 (05) : 683 - 683
  • [36] Surgical resection of brain metastases prolongs overall survival in non-small-cell lung cancer
    Yen, Chia-Te
    Wu, Wen-Jui
    Chen, Yen-Ting
    Chang, Wei-Chin
    Yang, Sheng-Hsiung
    Shen, Sheng-Yeh
    Su, Jian
    Chen, Hsuan-Yu
    AMERICAN JOURNAL OF CANCER RESEARCH, 2021, 11 (12): : 6160 - 6172
  • [37] Improving the Management of Brain Metastases in Oncogene-Addicted Non-Small-Cell Lung Cancer
    Fung, Andrea S.
    Leighl, Natasha B.
    JOURNAL OF ONCOLOGY PRACTICE, 2019, 15 (11) : 571 - +
  • [38] Brain metastases: the need for a more tailored approach in non-small-cell lung cancer patients
    Pablo Martínez
    Enriqueta Felip
    Clinical and Translational Oncology, 2012, 14 : 1 - 2
  • [39] BRAIN METASTASES AS A FIRST SITE OF RECURRENCE IN SURGICALLY RESECTED NON-SMALL-CELL LUNG CANCER
    Chang, Won Jin
    Choi, Moon Ki
    Hong, Jung Yong
    Kim, Moonjin
    Lee, Su Jin
    Park, Silvia
    Kim, Sungmin
    Lee, Ji Yun
    Lim, Sung Hee
    Sun, Jong-Mu
    Ahn, Jin Seok
    Park, Keunchil
    Ahn, Myung-Ju
    JOURNAL OF THORACIC ONCOLOGY, 2013, 8 : S926 - S926
  • [40] Three Treatments for EGFR-Mutant Non-Small-Cell Lung Cancer with Brain Metastases
    Fan, Y.
    Yu, X.
    Wang, H.
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (11) : S2228 - S2228
12345