DD Genotype of the angiotensin-converting enzyme gene and stroke in Slovenian population

被引：9
|
作者：
Peterlin, B
Milanez, T
Kobal, J
Peterlin-Potisk, K
Petrovic, D
Grad, A
Pogacnik, T
机构：
[1] UMC Ljubljana, Dept Obstet & Gynecol, Div Med Genet, Ljubljana 1000, Slovenia
[2] UMC Ljubljana, Dept Neurol, Ljubljana 1000, Slovenia
[3] Inst Rehabil, Ljubljana 1000, Slovenia
[4] Univ Ljubljana, Fac Med, Inst Histol & Embryol, Ljubljana 1000, Slovenia
来源：
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY | 2000年 / 439卷 / 03期
关键词：
angiotensin-converting enzyme; genetic polymorphism; risk factor; stroke;
D O I：
10.1007/s004240000083
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
The angiotensin-converting enzyme (ACE) is a rate-limiting enzyme in the renin angiotensin system, the enzyme is involved in the vascular remodelling and atherosclerosis. Its significance in pathogenesis of ischemic cerebrovascular insults (CVI) is not known. We analysed 124 Slovenian patients with CVI and compared them with 161 healthy controls for I/D polymorphism. Under a recessive model (chi(2) = 1.76, p = 0.1, OR = 1.40, 95% CI: 0.85 - 2.34) we found no significant difference in VD genotypes between patients with CVI and controls. This study shows that in a group of Slovenian CVI patients the DD genotype is not an important risk factor for the development of stroke.
引用
收藏
页码：R38 / R39
页数：2
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