Synthesis of some novel ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano [2, 3-b] pyridine-3-carboxylate derivatives

被引：0

作者：

Kumar, N. Vasanth ^{[1
]}

Mashelker, Uday C. ^{[1
]}

机构：

[1] SS&LS Patkar Coll, Organ Res Lab, Bombay 400062, Maharashtra, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2006年 / 45卷 / 07期

关键词：

pyridine; pyridine-3-carboxylates; antihypertensive activity;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl 5-methyl-6-cyano-7-substituted-2-oxo-2H-pyrano[2, 3-b]pyridine-3-carboxylates 4a-j have been prepared starting from 2, 6-dihyroxy-3-cyano-4-methyl pyridine 1. The compound 1 reacts with N,N-dimethylaminoethylenemalonate in acetic acid under reflux conditions to give 5-methyl-6-cyano-7-hydroxy -2H-pyrano[2,3-b]pyridine-2-one 2, which is further treated with phosphorous oxychloride to obtain ethyl 5-methyl-6-cyano-7chloro-2-oxo-2H-pyrano[2,3-b]pyridine-3-carboxylate 3. This chloride derivative 3 is finally converted to various amino derivatives 4a-j by condensation with corresponding amines. These compounds are expected to have alntihypertensive activity.

引用

页码：1770 / 1773

页数：4

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