Magnetic nanoparticles-based drug and gene delivery systems for the treatment of pulmonary diseases

被引：48

作者：

El-Sherbiny, Ibrahim M. ^{[1
]}

Elbaz, Nancy M. ^{[1
]}

Sedki, Mohammed ^{[1
]}

Elgammal, Abdulaziz ^{[1
]}

Yacoub, Magdi H. ^{[2
]}

机构：

[1] Zewail City Sci & Technol, Nanomat Lab, Ctr Mat Sci, Giza 12588, Egypt

[2] Imperial Coll, Natl Heart & Lung Inst, Harefield Heart Sci Ctr, London, England

来源：

NANOMEDICINE | 2017年 / 12卷 / 04期

关键词：

cystic fibrosis; hyperthermia; iron oxide nanoparticles; lung cancer; magnetic nanoparticles; targeted drug delivery; IRON-OXIDE NANOPARTICLES; CELL LUNG-CANCER; IN-VITRO; MAGNETOHYDRODYNAMIC THERMOCHEMOTHERAPY; CHITOSAN NANOPARTICLES; FOLATE RECEPTOR; ANTITUMOR DRUG; HYPERTHERMIA; THERAPY; HEAT;

D O I：

10.2217/nnm-2016-0341

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Magnetic nanoparticles (MNPs) have gained much attention due to their unique properties such as biocompatibility and biodegradability as well as magnetic and heat-medicated characteristics. Due to these inherent properties, MNPs have been widely used in various biomedical applications including targeted drug delivery and hyperthermia-based therapy. Hyperthermia is a promising approach for the thermal activation therapy of several diseases, including pulmonary diseases. Additionally, due to their large loading capacity and controlled release ability, several MNP-based drug delivery systems have been emerged for treatment of cystic fibrosis and lung cancer. This review provides an overview on the unique properties of MNPs and magnetic-mediated hyperthermia with emphasis on the recent biomedical applications of MNPs in treatment of both lung cancer and cystic fibrosis. [GRAPHICS] .

引用

页码：387 / 402

页数：16

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