PPARβ/δ activation of CD300a controls intestinal immunity

被引：27

作者：

Tanaka, Toshiya ^{[1
]}

Tahara-Hanaoka, Satoko ^{[2
,3
]}

Nabekura, Tsukasa ^{[2
,3
]}

Ikeda, Kaori ^{[1
]}

Jiang, Shuying ^{[4
,5
]}

Tsutsumi, Shuichi ^{[6
]}

Inagaki, Takeshi ^{[7
]}

Magoori, Kenta ^{[7
]}

Higurashi, Takuma ^{[8
]}

Takahashi, Hirokazu ^{[8
]}

Tachibana, Keisuke ^{[9
]}

Tsurutani, Yuya ^{[7
,10
]}

Raza, Sana ^{[1
]}

Anai, Motonobu ^{[1
]}

Minami, Takashi ^{[11
]}

Wada, Youichiro ^{[1
]}

Yokote, Koutaro ^{[10
]}

Doi, Takefumi ^{[9
]}

Hamakubo, Takao ^{[12
]}

Auwerx, Johan ^{[13
]}

Gonzalez, Frank J. ^{[14
]}

Nakajima, Atsushi ^{[8
]}

Aburatani, Hiroyuki ^{[6
]}

Naito, Makoto ^{[4
]}

Shibuya, Akira ^{[2
,3
]}

Kodama, Tatsuhiko ^{[1
]}

Sakai, Juro ^{[7
]}

机构：

[1] Univ Tokyo, RCAST, LSBM, Tokyo 1538904, Japan

[2] Univ Tsukuba, Fac Med, Ctr TARA, Dept Immunol, Tsukuba, Ibaraki 3058575, Japan

[3] Univ Tsukuba, Japan Sci & Technol Agcy, CREST, Tsukuba, Ibaraki 3058575, Japan

[4] Niigata Univ, Grad Sch Med & Dent Sci, Div Cellular & Mol Pathol, Niigata 9518510, Japan

[5] Peruseus Prote, Tokyo 1530041, Japan

[6] Univ Tokyo, RCAST, Genome Sci Div, Tokyo 1538904, Japan

[7] Univ Tokyo, RCAST, Div Metab Med, Tokyo 1538904, Japan

[8] Yokohama City Univ, Sch Med, Div Gastroenterol, Yokohama, Kanagawa 2360004, Japan

[9] Osaka Univ, Grad Sch Pharmaceut Sci, Osaka 5650871, Japan

[10] Chiba Univ, Grad Sch Med, Dept Clin Cell Biol & Med, Chiba 2608670, Japan

[11] Univ Tokyo, RCAST, Lab Vasc Biol, Tokyo 1538904, Japan

[12] Univ Tokyo, RCAST, Dept Quantitat Biol & Med, Tokyo 1538904, Japan

[13] Ecole Polytech Fed Lausanne, Lab Integrat & Syst Physiol, CH-1015 Lausanne, Switzerland

[14] NCI, Ctr Canc Res, Lab Metab, NIH, Bethesda, MD 20892 USA

来源：

SCIENTIFIC REPORTS | 2014年 / 4卷

关键词：

INNATE IMMUNITY; MAST-CELL; DELTA; MACROPHAGES; EXPRESSION; MICE; CHOLESTEROL; LYMPHOCYTES; REGULATORS; MICROBIOTA;

D O I：

10.1038/srep05412

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Macrophages are important for maintaining intestinal immune homeostasis. Here, we show that PPAR beta/delta (peroxisome proliferator-activated receptor beta/delta) directly regulates CD300a in macrophages that express the immunoreceptor tyrosine based-inhibitory motif (ITIM)-containing receptor. In mice lacking CD300a, high-fat diet (HFD) causes chronic intestinal inflammation with low numbers of intestinal lymph capillaries and dramatically expanded mesenteric lymph nodes. As a result, these mice exhibit triglyceride malabsorption and reduced body weight gain on HFD. Peritoneal macrophages from Cd300a(-/-) mice on HFD are classically M1 activated. Activation of toll-like receptor 4 (TLR4)/MyD88 signaling by lipopolysaccharide (LPS) results in prolonged IL-6 secretion in Cd300a(-/-) macrophages. Bone marrow transplantation confirmed that the phenotype originates from CD300a deficiency in leucocytes. These results identify CD300a-mediated inhibitory signaling in macrophages as a critical regulator of intestinal immune homeostasis.

引用

页数：9

共 50 条

[21] CD300a EXPRESSION IS MODULATED IN ATOPIC DERMATITIS AND COULD INFLUENCE THE INFLAMMATORY REPSONSE
Karra, L.
Gangwar, R. S.
Puzzovio, P. G.
Fyhrquist, N.
Minai-Fleminger, Y.
Landolina, N.
Levi, T.
Mankuta, D.
Simon, H.
Alenius, H.
Leibovici, V.
Simon, D.
Levi-Schaffer, F.
INFLAMMATION RESEARCH, 2019, 68 : 24 - 25
[22] CD300a binds to phosphatidylethanolamine and phosphatidylserine and modulates the uptake of dead cells.
Borrego, Francisco
Andersen, John
Calvo, Eric
Choi, Seung-Chul
Coligan, John
Simhadri, Venkateswara
JOURNAL OF IMMUNOLOGY, 2012, 188
[23] CD300a expression is modulated in atopic dermatitis and could influence the inflammatory response
Karra, Laila
Gangwar, Roopesh Singh
Puzzovio, Pier Giorgio
Fyhrquist, Nanna
Minai-Fleminger, Yael
Landolina, Nadine
Simon, Hans-Uwe
Alenius, Harri
Leibovici, Vera
Simon, Dagmar
Levi-Schaffer, Francesca
ALLERGY, 2019, 74 (07) : 1377 - 1380
[24] Autonomous regulation of mast cell degranulation through an inhibitory receptor CD300a
Wang, Y.
Nakahashi-Oda, C.
Shibuya, A.
EUROPEAN JOURNAL OF IMMUNOLOGY, 2019, 49 : 570 - 570
[25] Human Basophils Express the Inhibitory Receptor CD300a (IRp60)
Sabato, V.
Verweij, M.
Bridts, C.
De Clerck, L.
Stevens, W.
Schiavino, D.
Ebo, D.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2011, 127 (02) : AB75 - AB75
[26] The Stimulatory Role of CD300a in Diffuse Large B-Cell Lymphoma
Jiang, Lei
Zhou, Jeff Xiwu
Morse, Herbert
Xu, Yulian
BLOOD, 2014, 124 (21)
[27] The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
Lankry, Dikla
Rovis, Tihana Lenac
Jonjic, Stipan
Mandelboim, Ofer
EUROPEAN JOURNAL OF IMMUNOLOGY, 2013, 43 (08) : 2151 - 2161
[28] The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast
Bachelet, I
Munitz, A
Moretta, A
Moretta, L
Levi-Schaffer, F
JOURNAL OF IMMUNOLOGY, 2005, 175 (12): : 7989 - 7995
[29] Blockade of CD300A enhances the ability of human NK cells to lyse hematologic malignancies
Shuangcheng Li
Tianci Wang
Xinghui Xiao
Xiaodong Zheng
Haoyu Sun
Rui Sun
Hongdi Ma
Zhigang Tian
Xiaohu Zheng
Cancer Biology & Medicine, 2024, 21 (04) : 331 - 346
[30] Suppression of CD300A inhibits the growth of diffuse large B-cell lymphoma
Jiang, Lei
Xu, Yulian
Zeng, Xinli
Fang, Jianchen
Morse, Herbert C., III
Zhou, Jeff X.
ONCOTARGET, 2015, 6 (31) : 31191 - 31202

← 1 2 3 4 5 →