Transient Lymphopenia and Interstitial Pneumonia With Endotheliitis in SARS-CoV-2-Infected Macaques

被引：26

作者：

Koo, Bon-Sang ^{[1
]}

Oh, Hanseul ^{[1
]}

Kim, Green ^{[1
]}

Hwang, Eun-Ha ^{[1
]}

Jung, Hoyin ^{[1
]}

Lee, Youngjeon ^{[1
]}

Kang, Philyong ^{[2
]}

Park, Jae-Hak ^{[3
]}

Ryu, Choong-Min ^{[4
]}

Hong, Jung Joo ^{[1
]}

机构：

[1] Korea Res Inst Biosci & Biotechnol, Natl Primate Res Ctr, Cheongju, Chungcheongbuk, South Korea

[2] Korea Res Inst Biosciente & Biotechnol, Futurist Anim Resource Ctr, Cheongju, Chungcheongbuk, South Korea

[3] Seoul Natl Univ, Coll Vet Med, Dept Lab Anim Med, Seoul, South Korea

[4] Korea Res Inst Biosci & Biotechnol, Infect Dis Res Ctr, Daejeon, South Korea

来源：

JOURNAL OF INFECTIOUS DISEASES | 2020年 / 222卷 / 10期

关键词：

macaques; lymphopenia; pneumonia; SARS-CoV-2; INFECTION; SARS;

D O I：

10.1093/infdis/jiaa486

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Using a reliable primate model is critical for developing therapeutic advances to treat humans infected with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Here, we exposed macaques to high titers of SARS-CoV-2 via combined transmission routes. We observed acute interstitial pneumonia with endotheliitis in the lungs of all infected macaques. All macaques had a significant loss of total lymphocytes during infection, which were restored over time. These data show that SARS-CoV-2 causes a coronavirus disease 2019 (COVID-19)-like disease in macaques. This new model could investigate the interaction between SARS-CoV-2 and the immune system to test therapeutic strategies.

引用

页码：1596 / 1600

页数：5

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