Synthesis and Characterization of Poly(Methyl Methacrylate) PMMA and Evaluation of Cytotoxicity for Biomedical Application

被引：34

作者：

Feuser, Paulo E. ^{[1
]}

Gaspar, Pamela C. ^{[2
]}

Ricci-Junior, Eduardo ^{[3
]}

da Silva, Maria C. S. ^{[2
]}

Nele, Marcio ^{[4
]}

Sayer, Claudia ^{[1
]}

de Araujo, Pedro. H. H. ^{[1
]}

机构：

[1] Univ Fed Santa Catarina, Dept Chem Engn, BR-88040900 Florianopolis, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Clin Anal, BR-88040900 Florianopolis, SC, Brazil

[3] Univ Fed Rio de Janeiro, Coll Pharm, BR-21941 Rio De Janeiro, Brazil

[4] Univ Fed Rio de Janeiro, Sch Chem, BR-21941 Rio De Janeiro, Brazil

来源：

MACROMOLECULAR SYMPOSIA | 2014年 / 343卷 / 01期

关键词：

biomaterials; miniemulsion polymerization; nanoparticles; stability; MINIEMULSION POLYMERIZATION; DRUG-DELIVERY; NANOPARTICLES; STABILITY; NANOEMULSIONS;

D O I：

10.1002/masy.201300194

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The objective this work was the synthesis, characterization and evaluation of cytotoxicity poly(methyl methacrylate), PMMA, nanoparticles (NPs) produced using miniemulsion polymerization technique adopting azobisisobutylonitrile (AIBN) as initiator and biocompatible and biodegradable surfactant, lecithin and co-stabilizer, miglyol 812 The NPs showed high stability during one year and an average diameter of 89 nm with polydispersity index of 0.11 and a zeta potential -48 mV. The PMMA NPs were tested for cytotoxicity in acute monocytic leukemia cells (THP1) and in human lung adenocarcinoma cells (A549). The PMMA NPs did not show any adverse effect on cell viability indicating their potential to encapsulate antitumor agents.

引用

页码：65 / 69

页数：5

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