ART Adherence, Resistance, and Long-term HIV Viral Suppression in Postpartum Women

被引：7

作者：

Redd, Andrew D. ^{[1
,2
]}

Mukonda, Elton ^{[3
]}

Hu, Nai-Chung ^{[3
]}

Philips, Tamsin K. ^{[3
]}

Zerbe, Allison ^{[4
]}

Lesosky, Maia ^{[3
]}

Hsiao, Nei-Yuan ^{[5
,6
]}

Clarke, William ^{[7
]}

Reynolds, Steven J. ^{[1
,2
,8
]}

Abrams, Elaine J. ^{[4
,9
]}

Myer, Landon ^{[3
,10
]}

机构：

[1] NIAID, Lab Immunoregulat, NIH, Baltimore, MD USA

[2] Johns Hopkins Sch Med, Dept Med, Baltimore, MD USA

[3] Univ Cape Town, Div Epidemiol & Biostat, Cape Town, South Africa

[4] Columbia Univ, Mailman Sch Publ Hlth, ICAP, New York, NY USA

[5] Univ Cape Town, Dept Pathol, Div Med Virol, Cape Town, South Africa

[6] Groote Schuur Hosp, Natl Hlth Lab Serv, Cape Town, South Africa

[7] Johns Hopkins Sch Med, Dept Pathol, Baltimore, MD USA

[8] Rakai Hlth Sci Program, Kalisizo, Uganda

[9] Columbia Univ, Vagelos Coll Phys & Surg, New York, NY USA

[10] Univ Cape Town, Sch Publ Hlth & Family Med, Ctr Infect Dis Epidemiol & Res, Cape Town, South Africa

来源：

OPEN FORUM INFECTIOUS DISEASES | 2020年 / 7卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ART adherence; atiretrovirals; drug resistance; postpartum women; ANTIRETROVIRAL-THERAPY; PREVENTION; PREGNANCY;

D O I：

10.1093/ofid/ofaa346

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV+ South African women who achieved viral suppression during routine antenatal care, but later experienced a viremic episode (viral load >1000 copies/mL), were examined for presence of antiretrovirals and classified as "nonadherers" or "suboptimal adherers." Women were tested for drug resistance mutations (DRMs) at several time points and underwent viral load testing 36-60 months postpartum. Suboptimal adherers were more likely to have DRM detected during their viremic episode (P = .03) and at a subsequent viremic time point (P = .05). There was no difference in levels of viral suppression 36-60 months later in women with DRM detected vs women who had no evidence of DRM (P = .5).

引用

页数：4

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