Yttrium-Catalyzed Intramolecular Hydroalkoxylation/Claisen Rearrangement Sequence: Efficient Synthesis of Medium-Sized Lactams

被引：140

作者：

Zhou, Bo ^{[1
,2
]}

Li, Long ^{[1
,2
]}

Zhu, Xin-Qi ^{[1
,2
]}

Yan, Juan-Zhu ^{[1
,2
]}

Guo, Yi-Lin ^{[1
,2
]}

Ye, Long-Wu ^{[1
,2
,3
]}

机构：

[1] Xiamen Univ, Collaborat Innovat Ctr Chem Energy Mat, State Key Lab Phys Chem Solid Surfaces, Key Lab Chem Biol Fujian Prov, Xiamen 361005, Peoples R China

[2] Xiamen Univ, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China

[3] Chinese Acad Sci, State Key Lab Organomet Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2017年 / 56卷 / 14期

关键词：

cyclization; heterocycles; homogeneous catalysis; rearrangements; yttrium; RING-CLOSING METATHESIS; CLAISEN-TYPE REARRANGEMENT; C-H FUNCTIONALIZATION; ELECTROPHILIC REARRANGEMENTS; CASCADE REACTION; CHIRAL YNAMIDES; GOLD CATALYSIS; LACTONES; ALKYNES; ETHERS;

D O I：

10.1002/anie.201700596

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient yttrium-catalyzed intramolecular hydroalkoxylation/Claisen rearrangement sequence has been achieved, thus enabling facile access to a diverse array of valuable medium-sized lactams. Furthermore, a mechanistic rationale for this novel cascade reaction is well supported by a variety of control experiments.

引用

页码：4015 / 4019

页数：5

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